BDBM50192296 1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-5-methyl-3-oxiranylmethyl-1H-pyrimidine-2,4-dione::CHEMBL212867

SMILES: Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)n(CC2CO2)c1=O

InChI Key: InChIKey=AZWSLTONIFOIJA-DESBEWHSSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50192296   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50192296 (1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...) Show SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)n(CC2CO2)c1=O |c:21| Show InChI InChI=1S/C27H47N3O9SSi2/c1-17-12-30(24(32)29(22(17)31)13-18-14-35-18)23-21(38-42(10,11)26(5,6)7)27(19(28)16-40(33,34)39-27)20(37-23)15-36-41(8,9)25(2,3)4/h12,16,18,20-21,23H,13-15,28H2,1-11H3/t18?,20-,21+,23-,27-/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh School of Medicine Curated by ChEMBL					Assay Description Inhibition of FLAG-p66/HIS-p51-mediated HIV1 reverse transcriptase dimerization				J Med Chem 49: 4834-41 (2006) Article DOI: 10.1021/jm0604575 BindingDB Entry DOI: 10.7270/Q2GH9HKC
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50192296 (1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...) Show SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C=C3N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)n(CC2CO2)c1=O |c:21| Show InChI InChI=1S/C27H47N3O9SSi2/c1-17-12-30(24(32)29(22(17)31)13-18-14-35-18)23-21(38-42(10,11)26(5,6)7)27(19(28)16-40(33,34)39-27)20(37-23)15-36-41(8,9)25(2,3)4/h12,16,18,20-21,23H,13-15,28H2,1-11H3/t18?,20-,21+,23-,27-/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh School of Medicine Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase RNA-dependent DNA polymerase activity				J Med Chem 49: 4834-41 (2006) Article DOI: 10.1021/jm0604575 BindingDB Entry DOI: 10.7270/Q2GH9HKC
					More data for this Ligand-Target Pair