BDBM50192365 9-hydroxy-4-(3-methylphenyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::9-hydroxy-4-m-tolylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::CHEMBL380048

SMILES: Cc1cccc(c1)-c1cc2[nH]c3ccc(O)cc3c2c2C(=O)NC(=O)c12

InChI Key: InChIKey=ZRNUCMGCOSFBLJ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50192365   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50192365 (9-hydroxy-4-(3-methylphenyl)pyrrolo[3,4-c]carbazol...) Show SMILES Cc1cccc(c1)-c1cc2[nH]c3ccc(O)cc3c2c2C(=O)NC(=O)c12 Show InChI InChI=1S/C21H14N2O3/c1-10-3-2-4-11(7-10)13-9-16-17(19-18(13)20(25)23-21(19)26)14-8-12(24)5-6-15(14)22-16/h2-9,22,24H,1H3,(H,23,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition at human Chk1 in presence of 4 uM ATP				J Med Chem 49: 4896-911 (2006) Article DOI: 10.1021/jm0512591 BindingDB Entry DOI: 10.7270/Q23778BD
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50192365 (9-hydroxy-4-(3-methylphenyl)pyrrolo[3,4-c]carbazol...) Show SMILES Cc1cccc(c1)-c1cc2[nH]c3ccc(O)cc3c2c2C(=O)NC(=O)c12 Show InChI InChI=1S/C21H14N2O3/c1-10-3-2-4-11(7-10)13-9-16-17(19-18(13)20(25)23-21(19)26)14-8-12(24)5-6-15(14)22-16/h2-9,22,24H,1H3,(H,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Chulalongkorn University Curated by ChEMBL					Assay Description Inhibition of human Wee1				Eur J Med Chem 44: 1383-95 (2009) Article DOI: 10.1016/j.ejmech.2008.09.027 BindingDB Entry DOI: 10.7270/Q2X34XB6
					More data for this Ligand-Target Pair				3D Structure (docked)
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50192365 (9-hydroxy-4-(3-methylphenyl)pyrrolo[3,4-c]carbazol...) Show SMILES Cc1cccc(c1)-c1cc2[nH]c3ccc(O)cc3c2c2C(=O)NC(=O)c12 Show InChI InChI=1S/C21H14N2O3/c1-10-3-2-4-11(7-10)13-9-16-17(19-18(13)20(25)23-21(19)26)14-8-12(24)5-6-15(14)22-16/h2-9,22,24H,1H3,(H,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of human Wee1 in presence of 9.5 uM ATP				J Med Chem 49: 4896-911 (2006) Article DOI: 10.1021/jm0512591 BindingDB Entry DOI: 10.7270/Q23778BD
					More data for this Ligand-Target Pair				3D Structure (docked)