BDBM50192777 CHEMBL3915675

SMILES: Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2[C@H]3CC[C@@H]2C[C@@H](C3)OC(=O)NCCF)n1

InChI Key: InChIKey=MHVSNYZARVQBHO-PIIMJCKOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50192777   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human))	BDBM50192777 (CHEMBL3915675) Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2[C@H]3CC[C@@H]2C[C@@H](C3)OC(=O)NCCF)n1 |r| Show InChI InChI=1S/C24H27FN6O3S2/c1-13-21(36-14(2)28-13)19-12-35-23(29-19)30-20-6-3-15(11-27-20)22(32)31-16-4-5-17(31)10-18(9-16)34-24(33)26-8-7-25/h3,6,11-12,16-18H,4-5,7-10H2,1-2H3,(H,26,33)(H,27,29,30)/t16-,17+,18+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi& Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activation				Bioorg Med Chem Lett 26: 4936-4941 (2016) Article DOI: 10.1016/j.bmcl.2016.09.014 BindingDB Entry DOI: 10.7270/Q2154K06
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4 (Rattus norvegicus)	BDBM50192777 (CHEMBL3915675) Show SMILES Cc1nc(C)c(s1)-c1csc(Nc2ccc(cn2)C(=O)N2[C@H]3CC[C@@H]2C[C@@H](C3)OC(=O)NCCF)n1 |r| Show InChI InChI=1S/C24H27FN6O3S2/c1-13-21(36-14(2)28-13)19-12-35-23(29-19)30-20-6-3-15(11-27-20)22(32)31-16-4-5-17(31)10-18(9-16)34-24(33)26-8-7-25/h3,6,11-12,16-18H,4-5,7-10H2,1-2H3,(H,26,33)(H,27,29,30)/t16-,17+,18+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi& Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV4 assessed as inhibition of 4alpha-PDD-induced activation				Bioorg Med Chem Lett 26: 4936-4941 (2016) Article DOI: 10.1016/j.bmcl.2016.09.014 BindingDB Entry DOI: 10.7270/Q2154K06
					More data for this Ligand-Target Pair