BindingDB PrimarySearch

BDBM50192791 2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL437522

SMILES: CC(C)(Oc1ccc(Br)cn1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2

InChI Key: InChIKey=ZIMMKUOOHAWXLF-AYOVKPNZSA-N

Data: 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50192791
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50192791 (2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in HEK293 cells				Bioorg Med Chem Lett 16: 5414-9 (2006) Article DOI: 10.1016/j.bmcl.2006.07.055 BindingDB Entry DOI: 10.7270/Q28S4PJ0
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50192791 (2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1 expressed in Escherichia coli				Bioorg Med Chem Lett 16: 5414-9 (2006) Article DOI: 10.1016/j.bmcl.2006.07.055 BindingDB Entry DOI: 10.7270/Q28S4PJ0
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 2 (Homo sapiens (Human))	BDBM50192791 (2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD2				Bioorg Med Chem Lett 16: 5414-9 (2006) Article DOI: 10.1016/j.bmcl.2006.07.055 BindingDB Entry DOI: 10.7270/Q28S4PJ0
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) (Mus musculus (mouse))	BDBM50192791 (2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD2				Bioorg Med Chem Lett 16: 5414-9 (2006) Article DOI: 10.1016/j.bmcl.2006.07.055 BindingDB Entry DOI: 10.7270/Q28S4PJ0
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50192791 (2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in Escherichia coli				Bioorg Med Chem Lett 16: 5414-9 (2006) Article DOI: 10.1016/j.bmcl.2006.07.055 BindingDB Entry DOI: 10.7270/Q28S4PJ0
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair