BDBM50192822 CHEMBL3897222

SMILES: [H][C@]12CC[C@]([H])(C\C(C1)=N/OCCCO)N2C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1

InChI Key: InChIKey=OYBGPVIUTFUDEM-HAFACEDCSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50192822   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human))	BDBM50192822 (CHEMBL3897222) Show SMILES [H][C@]12CC[C@]([H])(C\C(C1)=N/OCCCO)N2C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1 |r| Show InChI InChI=1S/C24H28N6O3S2/c1-14-22(35-15(2)26-14)20-13-34-24(27-20)28-21-7-4-16(12-25-21)23(32)30-18-5-6-19(30)11-17(10-18)29-33-9-3-8-31/h4,7,12-13,18-19,31H,3,5-6,8-11H2,1-2H3,(H,25,27,28)/b29-17-/t18-,19+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi& Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human TRPV4 assessed as inhibition of 4alpha-PDD-induced activation				Bioorg Med Chem Lett 26: 4936-4941 (2016) Article DOI: 10.1016/j.bmcl.2016.09.014 BindingDB Entry DOI: 10.7270/Q2154K06
					More data for this Ligand-Target Pair
Vanilloid receptor (Rattus norvegicus)	BDBM50192822 (CHEMBL3897222) Show SMILES [H][C@]12CC[C@]([H])(C\C(C1)=N/OCCCO)N2C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1 |r| Show InChI InChI=1S/C24H28N6O3S2/c1-14-22(35-15(2)26-14)20-13-34-24(27-20)28-21-7-4-16(12-25-21)23(32)30-18-5-6-19(30)11-17(10-18)29-33-9-3-8-31/h4,7,12-13,18-19,31H,3,5-6,8-11H2,1-2H3,(H,25,27,28)/b29-17-/t18-,19+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi& Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at rat TRPV4 assessed as inhibition of 4alpha-PDD-induced activation				Bioorg Med Chem Lett 26: 4936-4941 (2016) Article DOI: 10.1016/j.bmcl.2016.09.014 BindingDB Entry DOI: 10.7270/Q2154K06
					More data for this Ligand-Target Pair