BDBM50193011 CHEMBL3945602
SMILES: CC(C)C1CCC(=CC1)c1onc(C(O)=Nc2c(C)n(C)n(C3CCCCC3)c2=O)c1C
InChI Key: InChIKey=HRTYJBLUZWWQGU-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E3 ubiquitin-protein ligase SMURF1 (Homo sapiens (Human)) | BDBM50193011 (CHEMBL3945602) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL | Assay Description Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil... | ACS Med Chem Lett 7: 878-880 (2016) Article DOI: 10.1021/acsmedchemlett.6b00326 BindingDB Entry DOI: 10.7270/Q2CF9S2B | |||||||||||
More data for this Ligand-Target Pair |