Found 27 hits for monomerid = 50193145 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Prolyl 4-hydroxylase
(Paramecium bursaria Chlorella virus 1) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/TrEMBL
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| Article PubMed
| 710 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in... |
Bioorg Med Chem 27: 2405-2412 (2019)
Article DOI: 10.1016/j.bmc.2019.01.018 |
More data for this Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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| PDB PubMed
| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assay |
ACS Med Chem Lett 11: 1416-1420 (2020)
|
More data for this Ligand-Target Pair | 3D Structure (crystal) |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford
| Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... |
ACS Chem Biol 8: 1488-96 (2013)
Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF |
More data for this Ligand-Target Pair | |
Lysine-specific demethylase 3A
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford
| Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... |
ACS Chem Biol 8: 1488-96 (2013)
Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF |
More data for this Ligand-Target Pair | |
Homo sapiens lysine demethylase 2A (KDM2A)
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford
| Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... |
ACS Chem Biol 8: 1488-96 (2013)
Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF |
More data for this Ligand-Target Pair | |
Lysine-specific demethylase 5C
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 5.50E+5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford
| Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... |
ACS Chem Biol 8: 1488-96 (2013)
Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF |
More data for this Ligand-Target Pair | |
Histone Lysine Demethylase
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
KEGG
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| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford
| Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... |
ACS Chem Biol 8: 1488-96 (2013)
Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF |
More data for this Ligand-Target Pair | |
Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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Similars
| Article PubMed
| n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human BBOX pre-incubated for 10 mins using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay |
Bioorg Med Chem Lett 24: 4954-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.035 BindingDB Entry DOI: 10.7270/Q2D2207X |
More data for this Ligand-Target Pair | |
Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human BBOX pre-incubated for 1 min using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay |
Bioorg Med Chem Lett 24: 4954-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.035 BindingDB Entry DOI: 10.7270/Q2D2207X |
More data for this Ligand-Target Pair | |
Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | n/a | 1.22E+5 | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Binding affinity to human BBOX by tryptophan fluorescence quenching binding assay |
Bioorg Med Chem Lett 24: 4954-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.035 BindingDB Entry DOI: 10.7270/Q2D2207X |
More data for this Ligand-Target Pair | |
Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Binding affinity to human BBOX in presence of Fe(II) by tryptophan fluorescence quenching binding assay |
Bioorg Med Chem Lett 24: 4954-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.035 BindingDB Entry DOI: 10.7270/Q2D2207X |
More data for this Ligand-Target Pair | |
Gamma-butyrobetaine dioxygenase
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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Patents
Similars
| Article PubMed
| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human BBOX pre-incubated for 20 mins using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay |
Bioorg Med Chem Lett 24: 4954-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.09.035 BindingDB Entry DOI: 10.7270/Q2D2207X |
More data for this Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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| PDB Article PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sungkyunkwan University
Curated by ChEMBL
| Assay Description Inhibition of PHD2 in human Hep3B cells assessed as erythropoietin secretion by ELISA |
Bioorg Med Chem Lett 24: 3142-5 (2014)
Article DOI: 10.1016/j.bmcl.2014.05.003 BindingDB Entry DOI: 10.7270/Q2QN68F3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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| PDB PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant PHD2 (unknown origin) catalytic domain (181 to 426 residues) expressed in Escherichia coli BL21 (DE3) cells using boitinyla... |
ACS Med Chem Lett 6: 1236-40 (2015)
BindingDB Entry DOI: 10.7270/Q2RB76G9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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| PDB PubMed
| n/a | n/a | 424 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass... |
ACS Med Chem Lett 6: 1236-40 (2015)
BindingDB Entry DOI: 10.7270/Q2RB76G9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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| PDB Article PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human PHD2 at 293K temperature by solvent relaxation technique |
J Med Chem 53: 867-75 (2010)
Article DOI: 10.1021/jm901537q BindingDB Entry DOI: 10.7270/Q2JD4WWN |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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| PDB Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Inc
Curated by ChEMBL
| Assay Description Inhibition of human EGLN1 |
Bioorg Med Chem Lett 16: 5687-90 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.017 BindingDB Entry DOI: 10.7270/Q25Q4WXS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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| PDB Article PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sungkyunkwan University
Curated by ChEMBL
| Assay Description Inhibition of PHD2 (unknown origin) after 30 mins by fluorescence polarization assay |
Bioorg Med Chem Lett 23: 5953-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.067 BindingDB Entry DOI: 10.7270/Q2XK8H1J |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Alpha-ketoglutarate-dependent dioxygenase FTO
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as in... |
J Med Chem 56: 3680-8 (2013)
Article DOI: 10.1021/jm400193d BindingDB Entry DOI: 10.7270/Q21V5GBQ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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| PDB Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis |
J Med Chem 56: 547-55 (2013)
Article DOI: 10.1021/jm301583m BindingDB Entry DOI: 10.7270/Q26Q1ZJV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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| PDB Article PubMed
| n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis |
J Med Chem 56: 547-55 (2013)
Article DOI: 10.1021/jm301583m BindingDB Entry DOI: 10.7270/Q26Q1ZJV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
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| PDB Article PubMed
| n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc.
Curated by ChEMBL
| Assay Description Inhibition of human HIF-PHD2 assessed as reduction in HIF1-alpha binding to VBC complex using biotin-labeled HIF1-alpha peptide as substrate preincub... |
ACS Med Chem Lett 8: 1320-1325 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00404 BindingDB Entry DOI: 10.7270/Q21N83N8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 7.90E+4 | n/a | n/a | n/a | n/a |
Japan Tobacco Inc.
Curated by ChEMBL
| Assay Description Inhibition of PHD2 in human Hep3B cells assessed as increase in EPO release after 24 hrs by ELISA |
ACS Med Chem Lett 8: 1320-1325 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00404 BindingDB Entry DOI: 10.7270/Q21N83N8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc.
Curated by ChEMBL
| Assay Description Inhibition of PHD2 (181 to 426 residues) (unknown origin) using biotinylated CODD peptide as substrate preincubated for 15 mins followed by substrate... |
ACS Med Chem Lett 8: 1320-1325 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00404 BindingDB Entry DOI: 10.7270/Q21N83N8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Prolyl 4-hydroxylase
(Paramecium bursaria Chlorella virus 1) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in... |
Bioorg Med Chem 27: 2405-2412 (2019)
Article DOI: 10.1016/j.bmc.2019.01.018 |
More data for this Ligand-Target Pair | |
Jumonji domain-containing protein 2A (JMJD2A)
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford
| Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... |
ACS Chem Biol 8: 1488-96 (2013)
Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF |
More data for this Ligand-Target Pair | |
Jumonji domain-containing protein 2C (JMJD2C)
(Homo sapiens (Human)) | BDBM50193145
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17) | PDB MMDB
Reactome pathway
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
University of Oxford
| Assay Description Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o... |
ACS Chem Biol 8: 1488-96 (2013)
Article DOI: 10.1021/cb400088q BindingDB Entry DOI: 10.7270/Q29Z93HF |
More data for this Ligand-Target Pair | |