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BDBM50193407 CHEMBL537426::N1-[4-(trifluoromethoxy)benzenesulfonyl)-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexane hydrochloride

SMILES: CC(N[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12

InChI Key: InChIKey=WWABBSQIRKPECQ-LQCDLOPMSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50193407   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Calcium sensing receptor


(Rattus norvegicus)		BDBM50193407
PNG
(CHEMBL537426 | N1-[4-(trifluoromethoxy)benzenesulf...)
Show SMILES CC(N[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C25H27F3N2O3S/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)29-23-11-4-5-12-24(23)30-34(31,32)20-15-13-19(14-16-20)33-25(26,27)28/h2-3,6-10,13-17,23-24,29-30H,4-5,11-12H2,1H3/t17?,23-,24-/m1/s1
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Similars
Article
PubMed
n/an/a 5.40E+3n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation

J Med Chem 49: 5119-28 (2006)


Article DOI: 10.1021/jm051233+
BindingDB Entry DOI: 10.7270/Q2DJ5GFC
More data for this
Ligand-Target Pair