BDBM50193875 CHEMBL218551::N-(2,3-dimethylphenyl)-7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]triazin-3-amine::US8481536, 334
SMILES: Cc1cccc(Nc2nnc3cc(cc(C)c3n2)-c2c(C)cccc2C)c1C
InChI Key: InChIKey=NIGDIPSNADAWNH-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50193875 (CHEMBL218551 | N-(2,3-dimethylphenyl)-7-(2,6-dimet...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TargeGen, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant Src kinase | Bioorg Med Chem Lett 16: 5546-50 (2006) Article DOI: 10.1016/j.bmcl.2006.08.035 BindingDB Entry DOI: 10.7270/Q2SN08MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50193875 (CHEMBL218551 | N-(2,3-dimethylphenyl)-7-(2,6-dimet...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 25 |
TargeGen, Inc. US Patent | Assay Description Testing of inhibition of kinases in vitro using luciferase-based assay from KinaseGlo, Promega Corp. | US Patent US8481536 (2013) BindingDB Entry DOI: 10.7270/Q2GB22PZ | |||||||||||
More data for this Ligand-Target Pair |