BDBM50193977 1-[4-chloro-3-(dimethylsulfamoyl)-2-hydroxyphenyl]-2-cyano-3-(2-phenylphenyl)guanidine::CHEMBL425985

SMILES: CN(C)S(=O)(=O)c1c(Cl)ccc(N=C(NC#N)Nc2ccccc2-c2ccccc2)c1O

InChI Key: InChIKey=IYZWLQHDOCJREA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50193977   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50193977 (1-[4-chloro-3-(dimethylsulfamoyl)-2-hydroxyphenyl]...) Show SMILES CN(C)S(=O)(=O)c1c(Cl)ccc(N=C(NC#N)Nc2ccccc2-c2ccccc2)c1O |w:12.11| Show InChI InChI=1S/C22H20ClN5O3S/c1-28(2)32(30,31)21-17(23)12-13-19(20(21)29)27-22(25-14-24)26-18-11-7-6-10-16(18)15-8-4-3-5-9-15/h3-13,29H,1-2H3,(H2,25,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Displacement of [125I]IL8 from CXCR2 expressed in CHO cells				Bioorg Med Chem Lett 16: 5513-6 (2006) Article DOI: 10.1016/j.bmcl.2006.08.042 BindingDB Entry DOI: 10.7270/Q2NV9HWD
					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50193977 (1-[4-chloro-3-(dimethylsulfamoyl)-2-hydroxyphenyl]...) Show SMILES CN(C)S(=O)(=O)c1c(Cl)ccc(N=C(NC#N)Nc2ccccc2-c2ccccc2)c1O |w:12.11| Show InChI InChI=1S/C22H20ClN5O3S/c1-28(2)32(30,31)21-17(23)12-13-19(20(21)29)27-22(25-14-24)26-18-11-7-6-10-16(18)15-8-4-3-5-9-15/h3-13,29H,1-2H3,(H2,25,26,27)	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	752	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Displacement of [125I]IL8 from CXCR1 expressed in CHO cells				Bioorg Med Chem Lett 16: 5513-6 (2006) Article DOI: 10.1016/j.bmcl.2006.08.042 BindingDB Entry DOI: 10.7270/Q2NV9HWD
					More data for this Ligand-Target Pair