BDBM50193983 1-[4-chloro-3-(dimethylsulfamoyl)-2-hydroxyphenyl]-2-cyano-3-[2-(propan-2-yl)phenyl]guanidine::CHEMBL218334

SMILES: CC(C)c1ccccc1NC(NC#N)=Nc1ccc(Cl)c(c1O)S(=O)(=O)N(C)C

InChI Key: InChIKey=MJYWNWXBXOJFTD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50193983   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-X-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50193983 (1-[4-chloro-3-(dimethylsulfamoyl)-2-hydroxyphenyl]...) Show SMILES CC(C)c1ccccc1NC(NC#N)=Nc1ccc(Cl)c(c1O)S(=O)(=O)N(C)C |w:14.15| Show InChI InChI=1S/C19H22ClN5O3S/c1-12(2)13-7-5-6-8-15(13)23-19(22-11-21)24-16-10-9-14(20)18(17(16)26)29(27,28)25(3)4/h5-10,12,26H,1-4H3,(H2,22,23,24)	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Displacement of [125I]IL8 from CXCR1 expressed in CHO cells				Bioorg Med Chem Lett 16: 5513-6 (2006) Article DOI: 10.1016/j.bmcl.2006.08.042 BindingDB Entry DOI: 10.7270/Q2NV9HWD
					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50193983 (1-[4-chloro-3-(dimethylsulfamoyl)-2-hydroxyphenyl]...) Show SMILES CC(C)c1ccccc1NC(NC#N)=Nc1ccc(Cl)c(c1O)S(=O)(=O)N(C)C |w:14.15| Show InChI InChI=1S/C19H22ClN5O3S/c1-12(2)13-7-5-6-8-15(13)23-19(22-11-21)24-16-10-9-14(20)18(17(16)26)29(27,28)25(3)4/h5-10,12,26H,1-4H3,(H2,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Displacement of [125I]IL8 from CXCR2 expressed in CHO cells				Bioorg Med Chem Lett 16: 5513-6 (2006) Article DOI: 10.1016/j.bmcl.2006.08.042 BindingDB Entry DOI: 10.7270/Q2NV9HWD
					More data for this Ligand-Target Pair