BDBM50194042 5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2-4-methylpiperazin-1-yl)ethyl)isothiazole-4-carboximidamide::CHEMBL214977

SMILES: CN1CCN(CCN=C(N)c2c(Nc3ccc(Oc4cc(Cl)ccc4Cl)cc3)s[nH]c2=O)CC1

InChI Key: InChIKey=JZLYYEVDXWGIGL-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50194042   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50194042 (5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...) Show SMILES CN1CCN(CCN=C(N)c2c(Nc3ccc(Oc4cc(Cl)ccc4Cl)cc3)s[nH]c2=O)CC1 |w:7.6| Show InChI InChI=1S/C23H26Cl2N6O2S/c1-30-10-12-31(13-11-30)9-8-27-21(26)20-22(32)29-34-23(20)28-16-3-5-17(6-4-16)33-19-14-15(24)2-7-18(19)25/h2-7,14,28H,8-13H2,1H3,(H2,26,27)(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	118	n/a	n/a	n/a	n/a
Valeant Pharmaceuticals Research & Development Curated by ChEMBL					Assay Description Inhibitory activity against MEK-1				Bioorg Med Chem Lett 16: 5561-6 (2006) Article DOI: 10.1016/j.bmcl.2006.08.048 BindingDB Entry DOI: 10.7270/Q2J38S5D
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50194042 (5-4-2,5-dichlorophenoxy)phenylamino)-3-hydroxy-N-2...) Show SMILES CN1CCN(CCN=C(N)c2c(Nc3ccc(Oc4cc(Cl)ccc4Cl)cc3)s[nH]c2=O)CC1 |w:7.6| Show InChI InChI=1S/C23H26Cl2N6O2S/c1-30-10-12-31(13-11-30)9-8-27-21(26)20-22(32)29-34-23(20)28-16-3-5-17(6-4-16)33-19-14-15(24)2-7-18(19)25/h2-7,14,28H,8-13H2,1H3,(H2,26,27)(H,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
Valeant Pharmaceuticals Research & Development Curated by ChEMBL					Assay Description Inhibition of MEK-1 activity				Bioorg Med Chem Lett 16: 5561-6 (2006) Article DOI: 10.1016/j.bmcl.2006.08.048 BindingDB Entry DOI: 10.7270/Q2J38S5D
					More data for this Ligand-Target Pair