BDBM50194315 (2R,2'S)-2-(1-methyl-2-pyrrolidinyl)-1,4-benzodioxane hydrochloride::(S)-2-((R)-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-1-methylpyrrolidine hydrochloride::CHEMBL481368
SMILES: CN1CCC[C@H]1[C@@H]1COc2ccccc2O1
InChI Key: InChIKey=UCVNDHGGPNSSQH-GWCFXTLKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuronal acetylcholine receptor (Rattus norvegicus (Rat)) | BDBM50194315 ((2R,2'S)-2-(1-methyl-2-pyrrolidinyl)-1,4-benzodiox...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Milano Pietro Pratesi Curated by ChEMBL | Assay Description Displacement of [3H]epibatidine from alpha4beta2 nAchR in rat brain cortex membrane | Bioorg Med Chem Lett 19: 854-9 (2009) Article DOI: 10.1016/j.bmcl.2008.12.002 BindingDB Entry DOI: 10.7270/Q29K4B2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor; alpha3/beta4 (Homo sapiens (Human)) | BDBM50194315 ((2R,2'S)-2-(1-methyl-2-pyrrolidinyl)-1,4-benzodiox...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano Curated by ChEMBL | Assay Description Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cells pretreated for 5 mins followed by [3H]epibatidine addition aft... | Eur J Med Chem 125: 1132-1144 (2017) Article DOI: 10.1016/j.ejmech.2016.10.048 BindingDB Entry DOI: 10.7270/Q2PZ5C8H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor (Rattus norvegicus (Rat)) | BDBM50194315 ((2R,2'S)-2-(1-methyl-2-pyrrolidinyl)-1,4-benzodiox...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Milano Pietro Pratesi Curated by ChEMBL | Assay Description Displacement of [125I]alphaBungarotoxin from alpha7 nAchR in rat brain cortex membrane | Bioorg Med Chem Lett 19: 854-9 (2009) Article DOI: 10.1016/j.bmcl.2008.12.002 BindingDB Entry DOI: 10.7270/Q29K4B2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor Alpha-4/Beta-2 (Homo sapiens (Human)) | BDBM50194315 ((2R,2'S)-2-(1-methyl-2-pyrrolidinyl)-1,4-benzodiox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano Curated by ChEMBL | Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in GH4CL cells by whole-cell patch clamp method | Eur J Med Chem 125: 1132-1144 (2017) Article DOI: 10.1016/j.ejmech.2016.10.048 BindingDB Entry DOI: 10.7270/Q2PZ5C8H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor; alpha3/beta4 (Homo sapiens (Human)) | BDBM50194315 ((2R,2'S)-2-(1-methyl-2-pyrrolidinyl)-1,4-benzodiox...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano Curated by ChEMBL | Assay Description Antagonist activity at human alpha3beta4 nAChR expressed in GH4CL cells by whole-cell patch clamp method | Eur J Med Chem 125: 1132-1144 (2017) Article DOI: 10.1016/j.ejmech.2016.10.048 BindingDB Entry DOI: 10.7270/Q2PZ5C8H | |||||||||||
More data for this Ligand-Target Pair |