BDBM50194644 (2R)-1-[(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidine-2-yl]carbonyl-N-((3R)-3-piperidinylmethyl)pyrrolidine-2-carboxamide::CHEMBL378885

SMILES: O[C@@H]1C[C@H](N(C1)C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N1CCC[C@@H]1C(=O)NC[C@@H]1CCCNC1

InChI Key: InChIKey=NKECRNQFOBAVDC-SVSXPMSYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50194644   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50194644 ((2R)-1-[(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropan...) Show SMILES O[C@@H]1C[C@H](N(C1)C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N1CCC[C@@H]1C(=O)NC[C@@H]1CCCNC1 Show InChI InChI=1S/C37H44N4O4/c42-31-22-33(36(45)40-21-11-19-32(40)35(44)39-25-27-12-10-20-38-24-27)41(26-31)34(43)23-37(28-13-4-1-5-14-28,29-15-6-2-7-16-29)30-17-8-3-9-18-30/h1-9,13-18,27,31-33,38,42H,10-12,19-26H2,(H,39,44)/t27-,31-,32-,33+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]NMS binding to human cloned M3 receptor expressed in CHO cells				J Med Chem 49: 5653-63 (2006) Article DOI: 10.1021/jm051205r BindingDB Entry DOI: 10.7270/Q2F76C6K
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50194644 ((2R)-1-[(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropan...) Show SMILES O[C@@H]1C[C@H](N(C1)C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N1CCC[C@@H]1C(=O)NC[C@@H]1CCCNC1 Show InChI InChI=1S/C37H44N4O4/c42-31-22-33(36(45)40-21-11-19-32(40)35(44)39-25-27-12-10-20-38-24-27)41(26-31)34(43)23-37(28-13-4-1-5-14-28,29-15-6-2-7-16-29)30-17-8-3-9-18-30/h1-9,13-18,27,31-33,38,42H,10-12,19-26H2,(H,39,44)/t27-,31-,32-,33+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]NMS binding to human cloned M4 receptor expressed in CHO cells				J Med Chem 49: 5653-63 (2006) Article DOI: 10.1021/jm051205r BindingDB Entry DOI: 10.7270/Q2F76C6K
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50194644 ((2R)-1-[(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropan...) Show SMILES O[C@@H]1C[C@H](N(C1)C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N1CCC[C@@H]1C(=O)NC[C@@H]1CCCNC1 Show InChI InChI=1S/C37H44N4O4/c42-31-22-33(36(45)40-21-11-19-32(40)35(44)39-25-27-12-10-20-38-24-27)41(26-31)34(43)23-37(28-13-4-1-5-14-28,29-15-6-2-7-16-29)30-17-8-3-9-18-30/h1-9,13-18,27,31-33,38,42H,10-12,19-26H2,(H,39,44)/t27-,31-,32-,33+/m1/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]NMS binding to human cloned M1 receptor expressed in CHO cells				J Med Chem 49: 5653-63 (2006) Article DOI: 10.1021/jm051205r BindingDB Entry DOI: 10.7270/Q2F76C6K
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50194644 ((2R)-1-[(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropan...) Show SMILES O[C@@H]1C[C@H](N(C1)C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N1CCC[C@@H]1C(=O)NC[C@@H]1CCCNC1 Show InChI InChI=1S/C37H44N4O4/c42-31-22-33(36(45)40-21-11-19-32(40)35(44)39-25-27-12-10-20-38-24-27)41(26-31)34(43)23-37(28-13-4-1-5-14-28,29-15-6-2-7-16-29)30-17-8-3-9-18-30/h1-9,13-18,27,31-33,38,42H,10-12,19-26H2,(H,39,44)/t27-,31-,32-,33+/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]NMS binding to human cloned M2 receptor expressed in CHO cells				J Med Chem 49: 5653-63 (2006) Article DOI: 10.1021/jm051205r BindingDB Entry DOI: 10.7270/Q2F76C6K
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50194644 ((2R)-1-[(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropan...) Show SMILES O[C@@H]1C[C@H](N(C1)C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N1CCC[C@@H]1C(=O)NC[C@@H]1CCCNC1 Show InChI InChI=1S/C37H44N4O4/c42-31-22-33(36(45)40-21-11-19-32(40)35(44)39-25-27-12-10-20-38-24-27)41(26-31)34(43)23-37(28-13-4-1-5-14-28,29-15-6-2-7-16-29)30-17-8-3-9-18-30/h1-9,13-18,27,31-33,38,42H,10-12,19-26H2,(H,39,44)/t27-,31-,32-,33+/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]NMS binding to human cloned M5 receptor expressed in CHO cells				J Med Chem 49: 5653-63 (2006) Article DOI: 10.1021/jm051205r BindingDB Entry DOI: 10.7270/Q2F76C6K
					More data for this Ligand-Target Pair