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BDBM50194697 4-methyl-N-(2-(3-methyl-2-oxoimidazolidin-1-yl)-5-(trifluoromethyl)phenyl)-3-(2-(methylamino)quinazolin-6-yl)benzamide::CHEMBL385598

SMILES: CNc1ncc2cc(ccc2n1)-c1cc(ccc1C)C(=O)Nc1cc(ccc1N1CCN(C)C1=O)C(F)(F)F

InChI Key: InChIKey=KQWCGDXCRBTZJV-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50194697   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50194697
PNG
(4-methyl-N-(2-(3-methyl-2-oxoimidazolidin-1-yl)-5-...)
Show SMILES CNc1ncc2cc(ccc2n1)-c1cc(ccc1C)C(=O)Nc1cc(ccc1N1CCN(C)C1=O)C(F)(F)F
Show InChI InChI=1S/C28H25F3N6O2/c1-16-4-5-18(13-21(16)17-6-8-22-19(12-17)15-33-26(32-2)35-22)25(38)34-23-14-20(28(29,30)31)7-9-24(23)37-11-10-36(3)27(37)39/h4-9,12-15H,10-11H2,1-3H3,(H,34,38)(H,32,33,35)
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n/an/a 461n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR by HTRF kinase assay


J Med Chem 49: 5671-86 (2006)


Article DOI: 10.1021/jm0605482
BindingDB Entry DOI: 10.7270/Q29G5MFD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50194697
PNG
(4-methyl-N-(2-(3-methyl-2-oxoimidazolidin-1-yl)-5-...)
Show SMILES CNc1ncc2cc(ccc2n1)-c1cc(ccc1C)C(=O)Nc1cc(ccc1N1CCN(C)C1=O)C(F)(F)F
Show InChI InChI=1S/C28H25F3N6O2/c1-16-4-5-18(13-21(16)17-6-8-22-19(12-17)15-33-26(32-2)35-22)25(38)34-23-14-20(28(29,30)31)7-9-24(23)37-11-10-36(3)27(37)39/h4-9,12-15H,10-11H2,1-3H3,(H,34,38)(H,32,33,35)
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n/an/a 4n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of p38-alpha by HTRF kinase assay


J Med Chem 49: 5671-86 (2006)


Article DOI: 10.1021/jm0605482
BindingDB Entry DOI: 10.7270/Q29G5MFD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM50194697
PNG
(4-methyl-N-(2-(3-methyl-2-oxoimidazolidin-1-yl)-5-...)
Show SMILES CNc1ncc2cc(ccc2n1)-c1cc(ccc1C)C(=O)Nc1cc(ccc1N1CCN(C)C1=O)C(F)(F)F
Show InChI InChI=1S/C28H25F3N6O2/c1-16-4-5-18(13-21(16)17-6-8-22-19(12-17)15-33-26(32-2)35-22)25(38)34-23-14-20(28(29,30)31)7-9-24(23)37-11-10-36(3)27(37)39/h4-9,12-15H,10-11H2,1-3H3,(H,34,38)(H,32,33,35)
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Article
PubMed
n/an/a 987n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Jak3 by HTRF kinase assay


J Med Chem 49: 5671-86 (2006)


Article DOI: 10.1021/jm0605482
BindingDB Entry DOI: 10.7270/Q29G5MFD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50194697
PNG
(4-methyl-N-(2-(3-methyl-2-oxoimidazolidin-1-yl)-5-...)
Show SMILES CNc1ncc2cc(ccc2n1)-c1cc(ccc1C)C(=O)Nc1cc(ccc1N1CCN(C)C1=O)C(F)(F)F
Show InChI InChI=1S/C28H25F3N6O2/c1-16-4-5-18(13-21(16)17-6-8-22-19(12-17)15-33-26(32-2)35-22)25(38)34-23-14-20(28(29,30)31)7-9-24(23)37-11-10-36(3)27(37)39/h4-9,12-15H,10-11H2,1-3H3,(H,34,38)(H,32,33,35)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lck by HTRF kinase assay


J Med Chem 49: 5671-86 (2006)


Article DOI: 10.1021/jm0605482
BindingDB Entry DOI: 10.7270/Q29G5MFD
More data for this
Ligand-Target Pair