BindingDB PrimarySearch

BDBM50194739 CHEMBL213216::diphenyl 1-[(N-2-thienyl-D-seryl)-L-alanyl]amino-2-(4-guanidinophenyl)ethanephosphonate

SMILES: [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]-[#6](=O)-c1cccs1)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1

InChI Key: InChIKey=MLDAHNABORMCIW-UMVYAPTFSA-N

Data: 5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50194739
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prothrombin (Homo sapiens (Human))	BDBM50194739 (CHEMBL213216 \| diphenyl 1-[(N-2-thienyl-D-seryl)-L...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human thrombin				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50194739 (CHEMBL213216 \| diphenyl 1-[(N-2-thienyl-D-seryl)-L...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human plasmin				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50194739 (CHEMBL213216 \| diphenyl 1-[(N-2-thienyl-D-seryl)-L...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of recombinant tPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Coagulation factor X (Bos taurus)	BDBM50194739 (CHEMBL213216 \| diphenyl 1-[(N-2-thienyl-D-seryl)-L...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of bovine F10a at 250 uM				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194739 (CHEMBL213216 \| diphenyl 1-[(N-2-thienyl-D-seryl)-L...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
University of Antwerp Curated by ChEMBL					More data for this Ligand-Target Pair