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BDBM50194772 CHEMBL3955728

SMILES: CNCCN1CCC(CC1)OCc1cccc(F)c1

InChI Key: InChIKey=HYQMJLIWAPDIFI-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50194772   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 8


(Homo sapiens (Human))
BDBM50194772
PNG
(CHEMBL3955728)
Show SMILES CNCCN1CCC(CC1)OCc1cccc(F)c1
Show InChI InChI=1S/C15H23FN2O/c1-17-7-10-18-8-5-15(6-9-18)19-12-13-3-2-4-14(16)11-13/h2-4,11,15,17H,5-10,12H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 1.85E+3n/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Inhibition of PRMT8 (unknown origin) assessed as inhibition of methylation activity measured after 3 hrs using [3H]-SAM by scintillation proximity as...


J Med Chem 59: 9124-9139 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01033
BindingDB Entry DOI: 10.7270/Q2028TGJ
More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens (Human))
BDBM50194772
PNG
(CHEMBL3955728)
Show SMILES CNCCN1CCC(CC1)OCc1cccc(F)c1
Show InChI InChI=1S/C15H23FN2O/c1-17-7-10-18-8-5-15(6-9-18)19-12-13-3-2-4-14(16)11-13/h2-4,11,15,17H,5-10,12H2,1H3
PDB

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>1.60E+4n/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Inhibition of PRMT1 (unknown origin) assessed as inhibition of methylation activity measured after 3 hrs using [3H]-SAM by scintillation proximity as...


J Med Chem 59: 9124-9139 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01033
BindingDB Entry DOI: 10.7270/Q2028TGJ
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 3


(Homo sapiens (Human))
BDBM50194772
PNG
(CHEMBL3955728)
Show SMILES CNCCN1CCC(CC1)OCc1cccc(F)c1
Show InChI InChI=1S/C15H23FN2O/c1-17-7-10-18-8-5-15(6-9-18)19-12-13-3-2-4-14(16)11-13/h2-4,11,15,17H,5-10,12H2,1H3
PDB

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>2.80E+4n/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) assessed as inhibition of methylation activity measured after 3 hrs using [3H]-SAM by scintillation proximity as...


J Med Chem 59: 9124-9139 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01033
BindingDB Entry DOI: 10.7270/Q2028TGJ
More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM50194772
PNG
(CHEMBL3955728)
Show SMILES CNCCN1CCC(CC1)OCc1cccc(F)c1
Show InChI InChI=1S/C15H23FN2O/c1-17-7-10-18-8-5-15(6-9-18)19-12-13-3-2-4-14(16)11-13/h2-4,11,15,17H,5-10,12H2,1H3
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 41n/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Inhibition of human full length PRMT4 (1 to 608 residues) expressed in 293F cells assessed as inhibition of methylation activity preincubated with pr...


J Med Chem 59: 9124-9139 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01033
BindingDB Entry DOI: 10.7270/Q2028TGJ
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM50194772
PNG
(CHEMBL3955728)
Show SMILES CNCCN1CCC(CC1)OCc1cccc(F)c1
Show InChI InChI=1S/C15H23FN2O/c1-17-7-10-18-8-5-15(6-9-18)19-12-13-3-2-4-14(16)11-13/h2-4,11,15,17H,5-10,12H2,1H3
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...


J Med Chem 59: 9124-9139 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01033
BindingDB Entry DOI: 10.7270/Q2028TGJ
More data for this
Ligand-Target Pair