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BDBM50194983 6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fluorophenylamino)-7-isopropylquinoline-3-carbonitrile::CHEMBL221006

SMILES: CC(C)Oc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NCc1cnc[nH]1

InChI Key: InChIKey=FZNUBZZLFQHEEG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50194983   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194983
PNG
(6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fl...)
Show SMILES CC(C)Oc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NCc1cnc[nH]1
Show InChI InChI=1S/C23H20ClFN6O/c1-13(2)32-22-7-20-17(6-21(22)29-11-16-10-27-12-30-16)23(14(8-26)9-28-20)31-15-3-4-19(25)18(24)5-15/h3-7,9-10,12-13,29H,11H2,1-2H3,(H,27,30)(H,28,31)
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>4.00E+4n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair