BDBM50194983 6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fluorophenylamino)-7-isopropylquinoline-3-carbonitrile::CHEMBL221006

SMILES: CC(C)Oc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NCc1cnc[nH]1

InChI Key: InChIKey=FZNUBZZLFQHEEG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50194983   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50194983 (6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fl...) Show SMILES CC(C)Oc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NCc1cnc[nH]1 Show InChI InChI=1S/C23H20ClFN6O/c1-13(2)32-22-7-20-17(6-21(22)29-11-16-10-27-12-30-16)23(14(8-26)9-28-20)31-15-3-4-19(25)18(24)5-15/h3-7,9-10,12-13,29H,11H2,1-2H3,(H,27,30)(H,28,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Tpl2 kinase by ELISA				Bioorg Med Chem Lett 16: 6067-72 (2006) Article DOI: 10.1016/j.bmcl.2006.08.102 BindingDB Entry DOI: 10.7270/Q2W958TR
					More data for this Ligand-Target Pair