BDBM50194992 4-((3-chloro-4-fluorophenyl)(methyl)amino)-6-(2-morpholinoethylamino)quinoline-3-carbonitrile::CHEMBL222202

SMILES: CN(c1ccc(F)c(Cl)c1)c1c(cnc2ccc(NCCN3CCOCC3)cc12)C#N

InChI Key: InChIKey=WRIDXMIWUUFSOV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50194992   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50194992 (4-((3-chloro-4-fluorophenyl)(methyl)amino)-6-(2-mo...) Show SMILES CN(c1ccc(F)c(Cl)c1)c1c(cnc2ccc(NCCN3CCOCC3)cc12)C#N Show InChI InChI=1S/C23H23ClFN5O/c1-29(18-3-4-21(25)20(24)13-18)23-16(14-26)15-28-22-5-2-17(12-19(22)23)27-6-7-30-8-10-31-11-9-30/h2-5,12-13,15,27H,6-11H2,1H3	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Tpl2 kinase by ELISA				Bioorg Med Chem Lett 16: 6067-72 (2006) Article DOI: 10.1016/j.bmcl.2006.08.102 BindingDB Entry DOI: 10.7270/Q2W958TR
					More data for this Ligand-Target Pair