BDBM50194997 6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fluorophenylamino)-2-hydroxyquinoline-3-carbonitrile::CHEMBL222882

SMILES: Fc1ccc(Nc2c(C#N)c(=O)[nH]c3ccc(NCc4cnc[nH]4)cc23)cc1Cl

InChI Key: InChIKey=KBAQVTZCCGAGHD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50194997   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50194997 (6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fl...) Show SMILES Fc1ccc(Nc2c(C#N)c(=O)[nH]c3ccc(NCc4cnc[nH]4)cc23)cc1Cl Show InChI InChI=1S/C20H14ClFN6O/c21-16-6-12(1-3-17(16)22)27-19-14-5-11(25-9-13-8-24-10-26-13)2-4-18(14)28-20(29)15(19)7-23/h1-6,8,10,25H,9H2,(H,24,26)(H2,27,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Tpl2 kinase by ELISA				Bioorg Med Chem Lett 16: 6067-72 (2006) Article DOI: 10.1016/j.bmcl.2006.08.102 BindingDB Entry DOI: 10.7270/Q2W958TR
					More data for this Ligand-Target Pair