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BDBM50195007 4-(3-chloro-4-fluorophenylamino)-6-(1-(pyridin-2-yl)ethylamino)quinoline-3-carbonitrile::CHEMBL221005

SMILES: CC(Nc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1)c1ccccn1

InChI Key: InChIKey=NCNDFNZUYLAINW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50195007   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195007
PNG
(4-(3-chloro-4-fluorophenylamino)-6-(1-(pyridin-2-y...)
Show SMILES CC(Nc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1)c1ccccn1
Show InChI InChI=1S/C23H17ClFN5/c1-14(21-4-2-3-9-27-21)29-16-6-8-22-18(10-16)23(15(12-26)13-28-22)30-17-5-7-20(25)19(24)11-17/h2-11,13-14,29H,1H3,(H,28,30)
PDB

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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair