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BDBM50195008 4-(3-chloro-4-fluorophenylamino)-6-(pyridin-2-ylmethylamino)quinoline-3-carbonitrile::CHEMBL374482

SMILES: Fc1ccc(Nc2c(cnc3ccc(NCc4ccccn4)cc23)C#N)cc1Cl

InChI Key: InChIKey=BEYSNYOQAFDZBA-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50195008   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50195008
PNG
(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-2-ylme...)
Show SMILES Fc1ccc(Nc2c(cnc3ccc(NCc4ccccn4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C22H15ClFN5/c23-19-10-16(4-6-20(19)24)29-22-14(11-25)12-28-21-7-5-15(9-18(21)22)27-13-17-3-1-2-8-26-17/h1-10,12,27H,13H2,(H,28,29)
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair