BDBM50195010 4-(3-chloro-4-fluorophenylamino)-6-phenethylquinoline-3-carbonitrile::CHEMBL222829

SMILES: Fc1ccc(Nc2c(cnc3ccc(CCc4ccccc4)cc23)C#N)cc1Cl

InChI Key: InChIKey=JNYUZBIDWMZOBL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50195010   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50195010 (4-(3-chloro-4-fluorophenylamino)-6-phenethylquinol...) Show SMILES Fc1ccc(Nc2c(cnc3ccc(CCc4ccccc4)cc23)C#N)cc1Cl Show InChI InChI=1S/C24H17ClFN3/c25-21-13-19(9-10-22(21)26)29-24-18(14-27)15-28-23-11-8-17(12-20(23)24)7-6-16-4-2-1-3-5-16/h1-5,8-13,15H,6-7H2,(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Tpl2 kinase by ELISA				Bioorg Med Chem Lett 16: 6067-72 (2006) Article DOI: 10.1016/j.bmcl.2006.08.102 BindingDB Entry DOI: 10.7270/Q2W958TR
					More data for this Ligand-Target Pair