BDBM50195012 6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fluorophenylamino)-2-methylquinoline-3-carbonitrile::CHEMBL223587

SMILES: Cc1nc2ccc(NCc3cnc[nH]3)cc2c(Nc2ccc(F)c(Cl)c2)c1C#N

InChI Key: InChIKey=AIIFXIIIFDPLGM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50195012   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50195012 (6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fl...) Show SMILES Cc1nc2ccc(NCc3cnc[nH]3)cc2c(Nc2ccc(F)c(Cl)c2)c1C#N Show InChI InChI=1S/C21H16ClFN6/c1-12-17(8-24)21(29-14-2-4-19(23)18(22)7-14)16-6-13(3-5-20(16)28-12)26-10-15-9-25-11-27-15/h2-7,9,11,26H,10H2,1H3,(H,25,27)(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Tpl2 kinase by ELISA				Bioorg Med Chem Lett 16: 6067-72 (2006) Article DOI: 10.1016/j.bmcl.2006.08.102 BindingDB Entry DOI: 10.7270/Q2W958TR
					More data for this Ligand-Target Pair