BDBM50195055 CHEMBL3954949

SMILES: CC1CCCC(C)N1C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1

InChI Key: InChIKey=UZFGAPNWQXVTKH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50195055   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 4 (Homo sapiens (Human))	BDBM50195055 (CHEMBL3954949) Show SMILES CC1CCCC(C)N1C(=O)c1ccc(Nc2nc(cs2)-c2sc(C)nc2C)nc1 Show InChI InChI=1S/C21H25N5OS2/c1-12-6-5-7-13(2)26(12)20(27)16-8-9-18(22-10-16)25-21-24-17(11-28-21)19-14(3)23-15(4)29-19/h8-13H,5-7H2,1-4H3,(H,22,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Shionogi& Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human recombinant TRPV4 expressed in CHO-K1 cells assessed as blockade of 1000 nM 4alphaPDD-induced calcium mobilization by FL...				Bioorg Med Chem Lett 26: 4930-4935 (2016) Article DOI: 10.1016/j.bmcl.2016.09.013 BindingDB Entry DOI: 10.7270/Q2BC41H5
					More data for this Ligand-Target Pair