Found 5 hits for monomerid = 50195181 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glycine transporter 2
(Homo sapiens (Human)) | BDBM50195181
(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)c(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28Cl2FN3O5S/c1-2-11-33(30,31)27-5-3-21(4-6-27,20(29)26-7-9-32-10-8-26)14-25-19(28)15-12-18(24)17(23)13-16(15)22/h12-13H,2-11,14H2,1H3,(H,25,28) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description Inhibition of human GlyT2 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131 BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this Ligand-Target Pair | |
Sodium- and chloride-dependent taurine transporter
(Homo sapiens (Human)) | BDBM50195181
(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)c(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28Cl2FN3O5S/c1-2-11-33(30,31)27-5-3-21(4-6-27,20(29)26-7-9-32-10-8-26)14-25-19(28)15-12-18(24)17(23)13-16(15)22/h12-13H,2-11,14H2,1H3,(H,25,28) | Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description Inhibition of human TauT |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131 BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this Ligand-Target Pair | |
Sodium- and chloride-dependent glycine transporter 1
(Mus musculus) | BDBM50195181
(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)c(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28Cl2FN3O5S/c1-2-11-33(30,31)27-5-3-21(4-6-27,20(29)26-7-9-32-10-8-26)14-25-19(28)15-12-18(24)17(23)13-16(15)22/h12-13H,2-11,14H2,1H3,(H,25,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description Inhibition of mouse GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131 BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this Ligand-Target Pair | |
Glycine transporter 1
(Homo sapiens (Human)) | BDBM50195181
(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)c(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28Cl2FN3O5S/c1-2-11-33(30,31)27-5-3-21(4-6-27,20(29)26-7-9-32-10-8-26)14-25-19(28)15-12-18(24)17(23)13-16(15)22/h12-13H,2-11,14H2,1H3,(H,25,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description Inhibition of human GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131 BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this Ligand-Target Pair | |
Glycine transporter 1
(attus norvegicus (Rat)) | BDBM50195181
(2,4-dichloro-5-fluoro-N-((4-(morpholine-4-carbonyl...)Show SMILES CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)c(Cl)cc2Cl)(CC1)C(=O)N1CCOCC1 Show InChI InChI=1S/C21H28Cl2FN3O5S/c1-2-11-33(30,31)27-5-3-21(4-6-27,20(29)26-7-9-32-10-8-26)14-25-19(28)15-12-18(24)17(23)13-16(15)22/h12-13H,2-11,14H2,1H3,(H,25,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description Inhibition of rat GlyT1 |
Bioorg Med Chem Lett 16: 5968-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.131 BindingDB Entry DOI: 10.7270/Q2C82B31 |
More data for this Ligand-Target Pair | |