BDBM50196337 2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(4-hydroxy-3-methoxy-benzyl)-thioureido]-propyl ester::2-((3-(4-hydroxy-3-methoxybenzyl)thioureido)methyl)-3-(3,4-dimethylphenyl)propyl pivalate::CHEMBL392495
SMILES: COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(C)c(C)c2)ccc1O
InChI Key: InChIKey=KDYVIORLSJSMTG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vanilloid receptor (Homo sapiens (Human)) | BDBM50196337 (2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | <10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital of the University of Pennsylvania Curated by ChEMBL | Assay Description Agonistic activity against vanilloid receptor 1 (TRPV1) | J Med Chem 47: 2717-23 (2004) Article DOI: 10.1021/jm030560j BindingDB Entry DOI: 10.7270/Q2TQ6498 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vanilloid receptor (Rattus norvegicus (rat)) | BDBM50196337 (2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells | Bioorg Med Chem Lett 17: 214-9 (2006) Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vanilloid receptor (Rattus norvegicus (rat)) | BDBM50196337 (2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 17.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description In vitro binding affinity towards Rat Vanilloid receptor 1 (VR1) by [3H]-RTX displacement. | J Med Chem 46: 3116-26 (2003) Article DOI: 10.1021/jm030089u BindingDB Entry DOI: 10.7270/Q2SB4551 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vanilloid receptor (Rattus norvegicus (rat)) | BDBM50196337 (2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description Agonist activity at rat TRPV1 expressed in CHO cells assessed as maximal calcium uptake | Bioorg Med Chem Lett 17: 214-9 (2006) Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vanilloid receptor (Rattus norvegicus (rat)) | BDBM50196337 (2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.97 | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cells | J Med Chem 46: 3116-26 (2003) Article DOI: 10.1021/jm030089u BindingDB Entry DOI: 10.7270/Q2SB4551 | |||||||||||
More data for this Ligand-Target Pair |