null
SMILES: COc1cc(CNC(=S)NCC(COC(=O)C(C)(C)C)Cc2ccc(cc2)C(C)(C)C)ccc1O
InChI Key: InChIKey=TVYDDDOENZEUAG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM50196343 (2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description Displacement of [3H]RTX from human TRPV1 expressed in CHO cells after 60 mins by liquid scintillation counting analysis | Bioorg Med Chem Lett 24: 382-5 (2013) Article DOI: 10.1016/j.bmcl.2013.10.064 BindingDB Entry DOI: 10.7270/Q29K4CP9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat)) | BDBM50196343 (2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description In vitro binding affinity towards Rat Vanilloid receptor 1 (VR1) by [3H]-RTX displacement. | J Med Chem 46: 3116-26 (2003) Article DOI: 10.1021/jm030089u BindingDB Entry DOI: 10.7270/Q2SB4551 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat)) | BDBM50196343 (2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells | Bioorg Med Chem Lett 17: 214-9 (2006) Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM50196343 (2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description Agonist activity at human TRPV1 expressed in CHO cells assessed as 45Ca2+ uptake after 20 mins by liquid scintillation counting analysis | Bioorg Med Chem Lett 24: 382-5 (2013) Article DOI: 10.1016/j.bmcl.2013.10.064 BindingDB Entry DOI: 10.7270/Q29K4CP9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat)) | BDBM50196343 (2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description Agonist activity at rat TRPV1 expressed in CHO cells assessed as maximal calcium uptake | Bioorg Med Chem Lett 17: 214-9 (2006) Article DOI: 10.1016/j.bmcl.2006.09.059 BindingDB Entry DOI: 10.7270/Q27D2TSX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat)) | BDBM50196343 (2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.83 | n/a | n/a | n/a | n/a |
Seoul National University Curated by ChEMBL | Assay Description In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cells | J Med Chem 46: 3116-26 (2003) Article DOI: 10.1021/jm030089u BindingDB Entry DOI: 10.7270/Q2SB4551 | |||||||||||
More data for this Ligand-Target Pair |