BDBM50196458 (2S)-1-{(2S)-3-(1-benzyl-1H-4-imidazolyl)-2-[(2S)-6-oxohexahydro-2-pyridinylcarboxamido]azolane-propanoyl}azolane-2-carboxamide::CHEMBL389037
SMILES: NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)cn1)NC(=O)[C@@H]1CCCC(=O)N1
InChI Key: InChIKey=ICNQGPKTIHCJTK-UFYCRDLUSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thyrotropin-releasing hormone receptor 2 (Rattus norvegicus) | BDBM50196458 ((2S)-1-{(2S)-3-(1-benzyl-1H-4-imidazolyl)-2-[(2S)-...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR2 | Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50196458 ((2S)-1-{(2S)-3-(1-benzyl-1H-4-imidazolyl)-2-[(2S)-...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Displacement of [3H]N(1)-Me-His-TRH from TRHR1 | Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50196458 ((2S)-1-{(2S)-3-(1-benzyl-1H-4-imidazolyl)-2-[(2S)-...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Agonist activity at TRHR1 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activity | Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thyrotropin-releasing hormone receptor 2 (Rattus norvegicus) | BDBM50196458 ((2S)-1-{(2S)-3-(1-benzyl-1H-4-imidazolyl)-2-[(2S)-...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research Curated by ChEMBL | Assay Description Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activity | Bioorg Med Chem 15: 433-43 (2006) Article DOI: 10.1016/j.bmc.2006.09.045 BindingDB Entry DOI: 10.7270/Q2ZW1KJV | |||||||||||
More data for this Ligand-Target Pair |