Found 4 hits for monomerid = 50196764 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50196764
(CHEMBL3970271)Show SMILES CCOc1ccc(C[C@H]2CC[C@@H](CC2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 |r,wU:8.7,wD:11.14,(2.03,-1.64,;2.03,-3.18,;3.37,-3.95,;3.37,-5.49,;2.04,-6.26,;2.04,-7.81,;3.38,-8.57,;3.39,-10.11,;4.73,-10.88,;6.05,-10.09,;7.38,-10.87,;7.39,-12.41,;6.05,-13.18,;4.72,-12.42,;8.72,-13.18,;8.72,-14.72,;10.05,-12.41,;11.38,-13.18,;4.71,-7.8,;4.7,-6.26,;6.04,-5.49,;7.36,-6.25,;8.69,-5.48,;10.15,-5.96,;10.63,-7.42,;12.13,-7.74,;11.05,-4.72,;10.15,-3.48,;10.63,-2.01,;8.69,-3.95,;7.36,-3.17,;7.36,-1.63,;6.04,-3.95,)| Show InChI InChI=1S/C24H31N5O4/c1-4-18-20-21(29(3)27-18)24(31)26-22(25-20)17-13-15(8-11-19(17)33-5-2)12-14-6-9-16(10-7-14)23(30)28-32/h8,11,13-14,16,32H,4-7,9-10,12H2,1-3H3,(H,28,30)(H,25,26,31)/t14-,16- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Navarra
Curated by ChEMBL
| Assay Description Inhibition of full length recombinant human N-terminal GST-tagged PDE5A1 expressed in baculovirus infected Sf9 cells using cGMP as substrate after 30... |
J Med Chem 59: 8967-9004 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00908 BindingDB Entry DOI: 10.7270/Q2KP8448 |
More data for this Ligand-Target Pair | |
Cereblon/Histone deacetylase 6
(Homo sapiens (Human)) | BDBM50196764
(CHEMBL3970271)Show SMILES CCOc1ccc(C[C@H]2CC[C@@H](CC2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 |r,wU:8.7,wD:11.14,(2.03,-1.64,;2.03,-3.18,;3.37,-3.95,;3.37,-5.49,;2.04,-6.26,;2.04,-7.81,;3.38,-8.57,;3.39,-10.11,;4.73,-10.88,;6.05,-10.09,;7.38,-10.87,;7.39,-12.41,;6.05,-13.18,;4.72,-12.42,;8.72,-13.18,;8.72,-14.72,;10.05,-12.41,;11.38,-13.18,;4.71,-7.8,;4.7,-6.26,;6.04,-5.49,;7.36,-6.25,;8.69,-5.48,;10.15,-5.96,;10.63,-7.42,;12.13,-7.74,;11.05,-4.72,;10.15,-3.48,;10.63,-2.01,;8.69,-3.95,;7.36,-3.17,;7.36,-1.63,;6.04,-3.95,)| Show InChI InChI=1S/C24H31N5O4/c1-4-18-20-21(29(3)27-18)24(31)26-22(25-20)17-13-15(8-11-19(17)33-5-2)12-14-6-9-16(10-7-14)23(30)28-32/h8,11,13-14,16,32H,4-7,9-10,12H2,1-3H3,(H,28,30)(H,25,26,31)/t14-,16- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 515 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Navarra
Curated by ChEMBL
| Assay Description Inhibition of full length recombinant human N-terminal GST tagged HDAC6 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate ... |
J Med Chem 59: 8967-9004 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00908 BindingDB Entry DOI: 10.7270/Q2KP8448 |
More data for this Ligand-Target Pair | |
Histone deacetylase 2
(Homo sapiens (Human)) | BDBM50196764
(CHEMBL3970271)Show SMILES CCOc1ccc(C[C@H]2CC[C@@H](CC2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 |r,wU:8.7,wD:11.14,(2.03,-1.64,;2.03,-3.18,;3.37,-3.95,;3.37,-5.49,;2.04,-6.26,;2.04,-7.81,;3.38,-8.57,;3.39,-10.11,;4.73,-10.88,;6.05,-10.09,;7.38,-10.87,;7.39,-12.41,;6.05,-13.18,;4.72,-12.42,;8.72,-13.18,;8.72,-14.72,;10.05,-12.41,;11.38,-13.18,;4.71,-7.8,;4.7,-6.26,;6.04,-5.49,;7.36,-6.25,;8.69,-5.48,;10.15,-5.96,;10.63,-7.42,;12.13,-7.74,;11.05,-4.72,;10.15,-3.48,;10.63,-2.01,;8.69,-3.95,;7.36,-3.17,;7.36,-1.63,;6.04,-3.95,)| Show InChI InChI=1S/C24H31N5O4/c1-4-18-20-21(29(3)27-18)24(31)26-22(25-20)17-13-15(8-11-19(17)33-5-2)12-14-6-9-16(10-7-14)23(30)28-32/h8,11,13-14,16,32H,4-7,9-10,12H2,1-3H3,(H,28,30)(H,25,26,31)/t14-,16- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Navarra
Curated by ChEMBL
| Assay Description Inhibition of full length recombinant human C-terminal His-tagged HDAC2 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate ... |
J Med Chem 59: 8967-9004 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00908 BindingDB Entry DOI: 10.7270/Q2KP8448 |
More data for this Ligand-Target Pair | |
Histone deacetylase 1
(Homo sapiens (Human)) | BDBM50196764
(CHEMBL3970271)Show SMILES CCOc1ccc(C[C@H]2CC[C@@H](CC2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 |r,wU:8.7,wD:11.14,(2.03,-1.64,;2.03,-3.18,;3.37,-3.95,;3.37,-5.49,;2.04,-6.26,;2.04,-7.81,;3.38,-8.57,;3.39,-10.11,;4.73,-10.88,;6.05,-10.09,;7.38,-10.87,;7.39,-12.41,;6.05,-13.18,;4.72,-12.42,;8.72,-13.18,;8.72,-14.72,;10.05,-12.41,;11.38,-13.18,;4.71,-7.8,;4.7,-6.26,;6.04,-5.49,;7.36,-6.25,;8.69,-5.48,;10.15,-5.96,;10.63,-7.42,;12.13,-7.74,;11.05,-4.72,;10.15,-3.48,;10.63,-2.01,;8.69,-3.95,;7.36,-3.17,;7.36,-1.63,;6.04,-3.95,)| Show InChI InChI=1S/C24H31N5O4/c1-4-18-20-21(29(3)27-18)24(31)26-22(25-20)17-13-15(8-11-19(17)33-5-2)12-14-6-9-16(10-7-14)23(30)28-32/h8,11,13-14,16,32H,4-7,9-10,12H2,1-3H3,(H,28,30)(H,25,26,31)/t14-,16- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 672 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Navarra
Curated by ChEMBL
| Assay Description Inhibition of full length recombinant human C-terminal His/Flag-tagged HDAC1 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC subst... |
J Med Chem 59: 8967-9004 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00908 BindingDB Entry DOI: 10.7270/Q2KP8448 |
More data for this Ligand-Target Pair | |