BDBM50197103 (2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine::CHEMBL384474

SMILES: N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O

InChI Key: InChIKey=SRAFHGOPGVYULO-WISUUJSJSA-N

Data: 5 KI

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50197103   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor 3 (RAT)	BDBM50197103 ((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...) Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	330	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Binding affinity to full length rat GluA3				J Med Chem 56: 1614-28 (2013) Article DOI: 10.1021/jm301433m BindingDB Entry DOI: 10.7270/Q23F4R0N
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor 3 (RAT)	BDBM50197103 ((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...) Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Binding affinity to rat GluA3-LBD (GluK3-S1S2)				J Med Chem 56: 1614-28 (2013) Article DOI: 10.1021/jm301433m BindingDB Entry DOI: 10.7270/Q23F4R0N
					More data for this Ligand-Target Pair				3D Structure (crystal)
Excitatory amino acid transporter 2 (Homo sapiens (Human))	BDBM50197103 ((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...) Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Inhibition of human EAAT2 expressed in HEK293 cells by FLIPR membrane potential assay				J Med Chem 49: 6532-8 (2006) Article DOI: 10.1021/jm060822s BindingDB Entry DOI: 10.7270/Q2S46RMK
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 3 (Homo sapiens (Human))	BDBM50197103 ((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...) Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assay				J Med Chem 49: 6532-8 (2006) Article DOI: 10.1021/jm060822s BindingDB Entry DOI: 10.7270/Q2S46RMK
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50197103 ((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...) Show SMILES N[C@@H]([C@@H]1CC[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C7H11NO4/c8-5(7(11)12)3-1-2-4(3)6(9)10/h3-5H,1-2,8H2,(H,9,10)(H,11,12)/t3-,4+,5+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Inhibition of human EAAT1 expressed in HEK293 cells by FLIPR membrane potential assay				J Med Chem 49: 6532-8 (2006) Article DOI: 10.1021/jm060822s BindingDB Entry DOI: 10.7270/Q2S46RMK
					More data for this Ligand-Target Pair