null

SMILES: CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)Cc1ccc(cc1)C(=O)NCC(O)=O

InChI Key: InChIKey=DGSMGRSHJNRNSU-MYYQLPNJSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50197435   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50197435 (CHEMBL387814 | [4-({[4-((9S,11R,13S,14S,17S)-17-hy...) Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)Cc1ccc(cc1)C(=O)NCC(O)=O |c:18,t:11| Show InChI InChI=1S/C38H42N2O5/c1-4-18-38(45)19-17-33-31-15-11-27-20-29(41)14-16-30(27)35(31)32(21-37(33,38)2)25-9-12-28(13-10-25)40(3)23-24-5-7-26(8-6-24)36(44)39-22-34(42)43/h5-10,12-13,20,31-33,45H,11,14-17,19,21-23H2,1-3H3,(H,39,44)(H,42,43)/t31-,32+,33-,37-,38-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of radiolabeled Dexamethasone from human GR				Bioorg Med Chem Lett 17: 40-4 (2006) Article DOI: 10.1016/j.bmcl.2006.10.001 BindingDB Entry DOI: 10.7270/Q2DR2W9G
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50197435 (CHEMBL387814 | [4-({[4-((9S,11R,13S,14S,17S)-17-hy...) Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)Cc1ccc(cc1)C(=O)NCC(O)=O |c:18,t:11| Show InChI InChI=1S/C38H42N2O5/c1-4-18-38(45)19-17-33-31-15-11-27-20-29(41)14-16-30(27)35(31)32(21-37(33,38)2)25-9-12-28(13-10-25)40(3)23-24-5-7-26(8-6-24)36(44)39-22-34(42)43/h5-10,12-13,20,31-33,45H,11,14-17,19,21-23H2,1-3H3,(H,39,44)(H,42,43)/t31-,32+,33-,37-,38-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human GR expressed in hGRAF cells				Bioorg Med Chem Lett 17: 40-4 (2006) Article DOI: 10.1016/j.bmcl.2006.10.001 BindingDB Entry DOI: 10.7270/Q2DR2W9G
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50197435 (CHEMBL387814 | [4-({[4-((9S,11R,13S,14S,17S)-17-hy...) Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)Cc1ccc(cc1)C(=O)NCC(O)=O |c:18,t:11| Show InChI InChI=1S/C38H42N2O5/c1-4-18-38(45)19-17-33-31-15-11-27-20-29(41)14-16-30(27)35(31)32(21-37(33,38)2)25-9-12-28(13-10-25)40(3)23-24-5-7-26(8-6-24)36(44)39-22-34(42)43/h5-10,12-13,20,31-33,45H,11,14-17,19,21-23H2,1-3H3,(H,39,44)(H,42,43)/t31-,32+,33-,37-,38-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	36	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human GR transcriptional activation by HepTAT cells				Bioorg Med Chem Lett 17: 40-4 (2006) Article DOI: 10.1016/j.bmcl.2006.10.001 BindingDB Entry DOI: 10.7270/Q2DR2W9G
					More data for this Ligand-Target Pair