BDBM50197507 (S)-4-methoxy-2-{1-[(1R,2S)-2-(4-methoxy-phenyl)-cyclopropylcarbamoyl]-cyclopentylmethyl}-butyric acid::CHEMBL389061

SMILES: COCC[C@H](CC1(CCCC1)C(=O)N[C@@H]1C[C@H]1c1ccc(OC)cc1)C(O)=O

InChI Key: InChIKey=WAFMGROHMCCENJ-NZSAHSFTSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50197507   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neprilysin (Homo sapiens (Human))	BDBM50197507 ((S)-4-methoxy-2-{1-[(1R,2S)-2-(4-methoxy-phenyl)-c...) Show SMILES COCC[C@H](CC1(CCCC1)C(=O)N[C@@H]1C[C@H]1c1ccc(OC)cc1)C(O)=O Show InChI InChI=1S/C22H31NO5/c1-27-12-9-16(20(24)25)14-22(10-3-4-11-22)21(26)23-19-13-18(19)15-5-7-17(28-2)8-6-15/h5-8,16,18-19H,3-4,9-14H2,1-2H3,(H,23,26)(H,24,25)/t16-,18+,19-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	7.0	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human kidney NEP at pH 7				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50197507 ((S)-4-methoxy-2-{1-[(1R,2S)-2-(4-methoxy-phenyl)-c...) Show SMILES COCC[C@H](CC1(CCCC1)C(=O)N[C@@H]1C[C@H]1c1ccc(OC)cc1)C(O)=O Show InChI InChI=1S/C22H31NO5/c1-27-12-9-16(20(24)25)14-22(10-3-4-11-22)21(26)23-19-13-18(19)15-5-7-17(28-2)8-6-15/h5-8,16,18-19H,3-4,9-14H2,1-2H3,(H,23,26)(H,24,25)/t16-,18+,19-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13.8	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human kidney NEP at pH 7.4				Bioorg Med Chem 15: 142-59 (2006) Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J
					More data for this Ligand-Target Pair