Found 6 hits for monomerid = 50197690 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197690
(CHEMBL3976548)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1 Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50197690
(CHEMBL3976548)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1 Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human SRC by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197690
(CHEMBL3976548)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1 Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human KDR by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM50197690
(CHEMBL3976548)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1 Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR4 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50197690
(CHEMBL3976548)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1 Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50197690
(CHEMBL3976548)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1 Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |