BDBM50197958 CHEMBL3979367
SMILES: CC(C)[C@@]12CC[C@@](C)(O1)[C@H](CC\C(C)=C\CC\C(C)=C\C2)OC(C)=O
InChI Key: InChIKey=HVBACKJYWZTKCA-XSLBTUIJSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Signal transducer and activator of transcription 3 (Homo sapiens (Human)) | BDBM50197958 (CHEMBL3979367) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ del Piemonte Orientale Curated by ChEMBL | Assay Description Inhibition of IFNgamma-induced STAT3 activation in human HeLa cells expressing STAT3 (unknown origin) preincubated for 15 mins followed by IFN-gamma ... | J Nat Prod 79: 1762-8 (2016) Article DOI: 10.1021/acs.jnatprod.6b00141 BindingDB Entry DOI: 10.7270/Q2PC34BW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 3 (Mus musculus) | BDBM50197958 (CHEMBL3979367) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a |
Universit£ del Piemonte Orientale Curated by ChEMBL | Assay Description Agonist activity at mouse YFP-tagged TRPV3 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-2-AM dye based microscopic analys... | J Nat Prod 79: 1762-8 (2016) Article DOI: 10.1021/acs.jnatprod.6b00141 BindingDB Entry DOI: 10.7270/Q2PC34BW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat sensitive channel TRPV3 (Rattus norvegicus) | BDBM50197958 (CHEMBL3979367) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a |
Universit£ del Piemonte Orientale Curated by ChEMBL | Assay Description Activation of rat TRPV3 overexpressed in HEK293 cells assessed as increase in 2-aminoethoxydiphenyl borate-induced intracellular calcium concentratio... | J Nat Prod 79: 1762-8 (2016) Article DOI: 10.1021/acs.jnatprod.6b00141 BindingDB Entry DOI: 10.7270/Q2PC34BW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear factor NF-kappa-B (Homo sapiens (Human)) | BDBM50197958 (CHEMBL3979367) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ del Piemonte Orientale Curated by ChEMBL | Assay Description Inhibition of NFkappaB p65 activation (unknown origin) expressed in human HeLa cells assessed as inhibition of TNFalpha-induced NFkappaB p65 nuclear ... | J Nat Prod 79: 1762-8 (2016) Article DOI: 10.1021/acs.jnatprod.6b00141 BindingDB Entry DOI: 10.7270/Q2PC34BW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heat sensitive channel TRPV3 (Rattus norvegicus) | BDBM50197958 (CHEMBL3979367) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ del Piemonte Orientale Curated by ChEMBL | Assay Description Antagonist activity at rat TRPV3 overexpressed in HEK293 cells assessed as inhibition of thymol-induced increase in intracellular Ca2+ levels preincu... | J Nat Prod 79: 1762-8 (2016) Article DOI: 10.1021/acs.jnatprod.6b00141 BindingDB Entry DOI: 10.7270/Q2PC34BW | |||||||||||
More data for this Ligand-Target Pair |