BDBM50198284 1-((1H-indol-3-yl)methyl)-4-(3,4-dichlorophenyl)piperidin-4-ol::CHEMBL246637

SMILES: OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=YZIXUQBOLGXTJS-UHFFFAOYSA-N

Data: 5 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50198284   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50198284 (1-((1H-indol-3-yl)methyl)-4-(3,4-dichlorophenyl)pi...) Show SMILES OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H20Cl2N2O/c21-17-6-5-15(11-18(17)22)20(25)7-9-24(10-8-20)13-14-12-23-19-4-2-1-3-16(14)19/h1-6,11-12,23,25H,7-10,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuses Curated by ChEMBL					Assay Description Displacement of [125I]IABN from human dopamine D2L receptor expressed in HEK293 cells				J Med Chem 51: 6095-109 (2008) Article DOI: 10.1021/jm800532x BindingDB Entry DOI: 10.7270/Q2HM589Q
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50198284 (1-((1H-indol-3-yl)methyl)-4-(3,4-dichlorophenyl)pi...) Show SMILES OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H20Cl2N2O/c21-17-6-5-15(11-18(17)22)20(25)7-9-24(10-8-20)13-14-12-23-19-4-2-1-3-16(14)19/h1-6,11-12,23,25H,7-10,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [125I]IABN from human dopamine D2L receptor expressed in HEK293 cells				Bioorg Med Chem Lett 17: 745-9 (2007) Article DOI: 10.1016/j.bmcl.2006.10.076 BindingDB Entry DOI: 10.7270/Q2N879FG
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50198284 (1-((1H-indol-3-yl)methyl)-4-(3,4-dichlorophenyl)pi...) Show SMILES OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H20Cl2N2O/c21-17-6-5-15(11-18(17)22)20(25)7-9-24(10-8-20)13-14-12-23-19-4-2-1-3-16(14)19/h1-6,11-12,23,25H,7-10,13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	111	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 17: 745-9 (2007) Article DOI: 10.1016/j.bmcl.2006.10.076 BindingDB Entry DOI: 10.7270/Q2N879FG
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50198284 (1-((1H-indol-3-yl)methyl)-4-(3,4-dichlorophenyl)pi...) Show SMILES OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H20Cl2N2O/c21-17-6-5-15(11-18(17)22)20(25)7-9-24(10-8-20)13-14-12-23-19-4-2-1-3-16(14)19/h1-6,11-12,23,25H,7-10,13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	111	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuses Curated by ChEMBL					Assay Description Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cells				J Med Chem 51: 6095-109 (2008) Article DOI: 10.1021/jm800532x BindingDB Entry DOI: 10.7270/Q2HM589Q
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50198284 (1-((1H-indol-3-yl)methyl)-4-(3,4-dichlorophenyl)pi...) Show SMILES OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H20Cl2N2O/c21-17-6-5-15(11-18(17)22)20(25)7-9-24(10-8-20)13-14-12-23-19-4-2-1-3-16(14)19/h1-6,11-12,23,25H,7-10,13H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [125I]IABN from human dopamine D4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 17: 745-9 (2007) Article DOI: 10.1016/j.bmcl.2006.10.076 BindingDB Entry DOI: 10.7270/Q2N879FG
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50198284 (1-((1H-indol-3-yl)methyl)-4-(3,4-dichlorophenyl)pi...) Show SMILES OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H20Cl2N2O/c21-17-6-5-15(11-18(17)22)20(25)7-9-24(10-8-20)13-14-12-23-19-4-2-1-3-16(14)19/h1-6,11-12,23,25H,7-10,13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	41.5	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis				Bioorg Med Chem Lett 17: 745-9 (2007) Article DOI: 10.1016/j.bmcl.2006.10.076 BindingDB Entry DOI: 10.7270/Q2N879FG
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50198284 (1-((1H-indol-3-yl)methyl)-4-(3,4-dichlorophenyl)pi...) Show SMILES OC1(CCN(Cc2c[nH]c3ccccc23)CC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H20Cl2N2O/c21-17-6-5-15(11-18(17)22)20(25)7-9-24(10-8-20)13-14-12-23-19-4-2-1-3-16(14)19/h1-6,11-12,23,25H,7-10,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	15.3	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Antagonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of quinpirole stimulated mitogenesis				Bioorg Med Chem Lett 17: 745-9 (2007) Article DOI: 10.1016/j.bmcl.2006.10.076 BindingDB Entry DOI: 10.7270/Q2N879FG
					More data for this Ligand-Target Pair