BindingDB PrimarySearch

BDBM50198353 CHEMBL227753::CHEMBL534948::N-(2,6-dimethylphenyl)-5-[4-(1-methylpiperidin-3-ylmethoxy)phenyl]imidazo[1,5-a]pyrazin-8-amine hydrochloride

SMILES: CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1

InChI Key: InChIKey=ZMNIUTKMAXSZLK-UHFFFAOYSA-N

Data: 9 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50198353
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50198353 (CHEMBL227753 \| CHEMBL534948 \| N-(2,6-dimethylpheny...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem 15: 868-85 (2006) Article DOI: 10.1016/j.bmc.2006.10.041 BindingDB Entry DOI: 10.7270/Q2DZ094H
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50198353 (CHEMBL227753 \| CHEMBL534948 \| N-(2,6-dimethylpheny...) Show SMILES Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of cSrc by coupled spectrophotometric enzyme assay				Bioorg Med Chem 15: 868-85 (2006) Article DOI: 10.1016/j.bmc.2006.10.041 BindingDB Entry DOI: 10.7270/Q2DZ094H
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50198353 (CHEMBL227753 \| CHEMBL534948 \| N-(2,6-dimethylpheny...) Show SMILES Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of cSrc by coupled spectrophotometric enzyme assay				Bioorg Med Chem 15: 868-85 (2006) Article DOI: 10.1016/j.bmc.2006.10.041 BindingDB Entry DOI: 10.7270/Q2DZ094H
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50198353 (CHEMBL227753 \| CHEMBL534948 \| N-(2,6-dimethylpheny...) Show SMILES Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.73E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of EGFR				Bioorg Med Chem 15: 868-85 (2006) Article DOI: 10.1016/j.bmc.2006.10.041 BindingDB Entry DOI: 10.7270/Q2DZ094H
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50198353 (CHEMBL227753 \| CHEMBL534948 \| N-(2,6-dimethylpheny...) Show SMILES Show InChI	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of Lck				Bioorg Med Chem 15: 868-85 (2006) Article DOI: 10.1016/j.bmc.2006.10.041 BindingDB Entry DOI: 10.7270/Q2DZ094H
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM50198353 (CHEMBL227753 \| CHEMBL534948 \| N-(2,6-dimethylpheny...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of Syk				Bioorg Med Chem 15: 868-85 (2006) Article DOI: 10.1016/j.bmc.2006.10.041 BindingDB Entry DOI: 10.7270/Q2DZ094H
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM50198353 (CHEMBL227753 \| CHEMBL534948 \| N-(2,6-dimethylpheny...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of Zap70				Bioorg Med Chem 15: 868-85 (2006) Article DOI: 10.1016/j.bmc.2006.10.041 BindingDB Entry DOI: 10.7270/Q2DZ094H
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50198353 (CHEMBL227753 \| CHEMBL534948 \| N-(2,6-dimethylpheny...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of PKCbeta2				Bioorg Med Chem 15: 868-85 (2006) Article DOI: 10.1016/j.bmc.2006.10.041 BindingDB Entry DOI: 10.7270/Q2DZ094H
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50198353 (CHEMBL227753 \| CHEMBL534948 \| N-(2,6-dimethylpheny...) Show SMILES Show InChI	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					Assay Description Inhibition of cSrc in COS7 cells by ELISA				Bioorg Med Chem 15: 868-85 (2006) Article DOI: 10.1016/j.bmc.2006.10.041 BindingDB Entry DOI: 10.7270/Q2DZ094H
Kissei Pharmaceutical Company Ltd Curated by ChEMBL					More data for this Ligand-Target Pair