BDBM50198429 (S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]pyrimidin-2-yl)piperazin-1-yl)(piperidin-2-yl)methanone::CHEMBL233046
SMILES: Clc1ccc(CNc2nc(nc3ncccc23)N2CCN(CC2)C(=O)[C@@H]2CCCCN2)c(Cl)c1
InChI Key: InChIKey=GDQQUDANFRCFMF-FQEVSTJZSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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C-C chemokine receptor type 4 (CCR4) (Homo sapiens (Human)) | BDBM50198429 ((S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]py...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of MDC-induced chemotaxis in L1.2 cells expressing CCR4 | Bioorg Med Chem Lett 17: 679-82 (2007) Article DOI: 10.1016/j.bmcl.2006.10.091 BindingDB Entry DOI: 10.7270/Q24B310V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 4 (CCR4) (Homo sapiens (Human)) | BDBM50198429 ((S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]py...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Displacement of [125I]MDC from human CCR4 expressed in HEK293 cells | Bioorg Med Chem Lett 17: 679-82 (2007) Article DOI: 10.1016/j.bmcl.2006.10.091 BindingDB Entry DOI: 10.7270/Q24B310V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50198429 ((S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]py...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of hERG | Bioorg Med Chem Lett 17: 679-82 (2007) Article DOI: 10.1016/j.bmcl.2006.10.091 BindingDB Entry DOI: 10.7270/Q24B310V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 4 (CCR4) (Homo sapiens (Human)) | BDBM50198429 ((S)-(4-(4-(2,4-dichlorobenzylamino)pyrido[2,3-d]py...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Antagonist activity at human CCR4 expressed in CEMS529 cells assessed as effect on calcium mobilization | Bioorg Med Chem Lett 17: 679-82 (2007) Article DOI: 10.1016/j.bmcl.2006.10.091 BindingDB Entry DOI: 10.7270/Q24B310V | |||||||||||
More data for this Ligand-Target Pair |