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SMILES: Clc1ccc(cc1)-c1cc2ncn(-c3ccc4C=C(CN5CCCC5)CCc4c3)c(=O)c2s1

InChI Key: InChIKey=WUAXCPYYHBPYFR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50199249   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanin-concentrating hormone receptor 1


(Homo sapiens (Human))		BDBM50199249
PNG
(6-(4-chlorophenyl)-3-[6-(1-pyrrolidinylmethyl)-7,8...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4C=C(CN5CCCC5)CCc4c3)c(=O)c2s1 |t:18|
Show InChI InChI=1S/C27H24ClN3OS/c28-22-8-5-19(6-9-22)25-15-24-26(33-25)27(32)31(17-29-24)23-10-7-20-13-18(3-4-21(20)14-23)16-30-11-1-2-12-30/h5-10,13-15,17H,1-4,11-12,16H2
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Article
PubMed
n/an/a 0.870n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay

J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair