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BDBM50199252 6-(4-chlorophenyl)-3-[2-(piperidin-1-ylmethyl)-1-benzothien-5-yl]thieno[3,2-d]pyrimidin-4(3H)-one::CHEMBL437914

SMILES: Clc1ccc(cc1)-c1cc2ncn(-c3ccc4sc(CN5CCCCC5)cc4c3)c(=O)c2s1

InChI Key: InChIKey=PVFOJNGXRJKDMG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50199252   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50199252
PNG
(6-(4-chlorophenyl)-3-[2-(piperidin-1-ylmethyl)-1-b...)
Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4sc(CN5CCCCC5)cc4c3)c(=O)c2s1
Show InChI InChI=1S/C26H22ClN3OS2/c27-19-6-4-17(5-7-19)24-14-22-25(33-24)26(31)30(16-28-22)20-8-9-23-18(12-20)13-21(32-23)15-29-10-2-1-3-11-29/h4-9,12-14,16H,1-3,10-11,15H2
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Patents

Article
PubMed
n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay


J Med Chem 49: 7108-18 (2006)


Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT
More data for this
Ligand-Target Pair