BindingDB PrimarySearch

BDBM50199522 (+)-huperzine A::(+-)-HA::(-)-1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one(Huperzine A)::(-)-huperazine A::(-)-huperzine A::(-)1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one( (-)-Huperzine A)::(1R,9R)-1-Amino-13-eth-(E)-ylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::(R)-1-Amino-13-eth-(E)-ylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::(R)-1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::(huperazine A)(-)-1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::1-Amino-13-eth-(E)-ylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::1-Amino-13-eth-(Z)-ylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one::1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one((+/-)-Huperzine A)::1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.0*2,7*]trideca-2(7),3,10-trien-5-one((-)-Huperzine A)::1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0~2,7~]trideca-2(7),3,10-trien-5-one::CHEMBL395280::HUPERAINE A::Hyperazzine A

SMILES: C\C=C1/[C@@H]2Cc3[nH]c(=O)ccc3[C@@]1(N)CC(C)=C2

InChI Key: InChIKey=ZRJBHWIHUMBLCN-YQEJDHNASA-N

Data: 37 IC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 50199522
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	72.4	n/a	n/a	n/a	n/a	5.0	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of AChE in rat cortex at pH 5				Bioorg Med Chem 15: 1394-408 (2007) Article DOI: 10.1016/j.bmc.2006.11.009 BindingDB Entry DOI: 10.7270/Q27W6BTX
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cholinesterase (Canis lupus familiaris)	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+7	n/a	n/a	n/a	n/a	n/a	n/a
Hebei University Curated by ChEMBL					Assay Description Inhibition of dog serum BChE using butrylthiocholine iodide as substrate by spectrophotometry based Ellman's method				Bioorg Med Chem Lett 30: (2020)
Hebei University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Bos taurus (bovine))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description Inhibition of bovine AChE by Ellman's method				Bioorg Med Chem 16: 7450-6 (2008) Article DOI: 10.1016/j.bmc.2008.06.022 BindingDB Entry DOI: 10.7270/Q2NC611F
Università di Bari Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Fujian Normal University Curated by ChEMBL					Assay Description Inhibition of human acetylcholinesterase after 30 mins by microplate reader-based Ellman's method				J Nat Prod 78: 3067-70 (2015) BindingDB Entry DOI: 10.7270/Q2RX9DX7
Fujian Normal University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Tetronarce californica (Pacific electric ray) (Tor...)	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	11.4	n/a	n/a	n/a	n/a	n/a	n/a
The Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of Torpedo california AChE by Ellman's method				Bioorg Med Chem 17: 6937-41 (2009) Article DOI: 10.1016/j.bmc.2009.08.017 BindingDB Entry DOI: 10.7270/Q2J966GQ
The Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
The Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human AChE by Ellman's method				Bioorg Med Chem 17: 6937-41 (2009) Article DOI: 10.1016/j.bmc.2009.08.017 BindingDB Entry DOI: 10.7270/Q2J966GQ
The Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Winnipeg Curated by ChEMBL					Assay Description Inhibition of AChE by Ellman's method				J Nat Prod 73: 1858-62 (2010) Article DOI: 10.1021/np100494u BindingDB Entry DOI: 10.7270/Q2TM7BC0
The University of Winnipeg Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cholinesterases (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universitat de Barcelona Curated by ChEMBL					Assay Description Inhibition of butyrylcholinesterase (BChE) in human serum				J Med Chem 43: 4657-66 (2001) BindingDB Entry DOI: 10.7270/Q2Q52Q9B
Universitat de Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Bos taurus (bovine))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Universitat de Barcelona Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of acetylcholinesterase of bovine erythrocytes				J Med Chem 43: 4657-66 (2001) BindingDB Entry DOI: 10.7270/Q2Q52Q9B
Universitat de Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Universitat de Barcelona Curated by ChEMBL					Assay Description Inhibition of acetylcholinesterase isolated from Human erythrocytes.				J Med Chem 43: 4657-66 (2001) BindingDB Entry DOI: 10.7270/Q2Q52Q9B
Universitat de Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cholinesterases (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universitat de Barcelona Curated by ChEMBL					Assay Description Inhibition of butyrylcholinesterase (BChE) activity in human serum				J Med Chem 42: 3227-42 (1999) Article DOI: 10.1021/jm980620z BindingDB Entry DOI: 10.7270/Q2H70GH6
Universitat de Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Bos taurus (bovine))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Universitat de Barcelona Curated by ChEMBL					Assay Description Inhibition of acetylcholinesterase (AChE)activity in bovine erythrocytes				J Med Chem 42: 3227-42 (1999) Article DOI: 10.1021/jm980620z BindingDB Entry DOI: 10.7270/Q2H70GH6
Universitat de Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Bos taurus (bovine))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Universitat de Barcelona Curated by ChEMBL					Assay Description In vitro inhibitory concentration against bovine acetylcholinesterase enzyme				J Med Chem 44: 4733-6 (2001) BindingDB Entry DOI: 10.7270/Q2SF2WWD
Universitat de Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cholinesterases (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universitat de Barcelona Curated by ChEMBL					Assay Description In vitro inhibitory concentration against BChE of human serum				J Med Chem 44: 4733-6 (2001) BindingDB Entry DOI: 10.7270/Q2SF2WWD
Universitat de Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Universitat de Barcelona Curated by ChEMBL					Assay Description In vitro inhibitory concentration against acetylcholinesterase of human erythrocytes				J Med Chem 44: 4733-6 (2001) BindingDB Entry DOI: 10.7270/Q2SF2WWD
Universitat de Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description In vitro inhibitory concentration against rat cortex acetylcholinesterase				Bioorg Med Chem Lett 15: 3834-7 (2005) Article DOI: 10.1016/j.bmcl.2005.05.132 BindingDB Entry DOI: 10.7270/Q27H1KBV
Zhejiang University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Carboxylic ester hydrolase (Rattus norvegicus (rat))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.62E+4	n/a	n/a	n/a	n/a	n/a	n/a
Zhejiang University Curated by ChEMBL					Assay Description In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenate				Bioorg Med Chem Lett 15: 3834-7 (2005) Article DOI: 10.1016/j.bmcl.2005.05.132 BindingDB Entry DOI: 10.7270/Q27H1KBV
Zhejiang University Curated by ChEMBL					More data for this Ligand-Target Pair
Cholinesterases (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Aging Curated by ChEMBL					Assay Description Inhibitory concentration against human plasma Butyrylcholinesterase				J Med Chem 48: 986-94 (2005) Article DOI: 10.1021/jm049309+ BindingDB Entry DOI: 10.7270/Q2TM7BWQ
National Institute on Aging Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Aging Curated by ChEMBL					Assay Description Inhibitory concentration against human erythrocyte Acetylcholinesterase				J Med Chem 48: 986-94 (2005) Article DOI: 10.1021/jm049309+ BindingDB Entry DOI: 10.7270/Q2TM7BWQ
National Institute on Aging Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Bos taurus (bovine))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Hoshi University Curated by ChEMBL					Assay Description Inhibition of bovine acetylcholinesterase				Bioorg Med Chem 15: 7803-8 (2007) Article DOI: 10.1016/j.bmc.2007.08.043 BindingDB Entry DOI: 10.7270/Q2F190JK
Hoshi University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cholinesterases (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universitat de Barcelona Curated by ChEMBL					Assay Description Inhibition of human serum BChE				J Med Chem 49: 6833-40 (2006) Article DOI: 10.1021/jm060945c BindingDB Entry DOI: 10.7270/Q29K4C1S
Universitat de Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Universitat de Barcelona Curated by ChEMBL					Assay Description Inhibition of human erythrocyte AChE				J Med Chem 49: 6833-40 (2006) Article DOI: 10.1021/jm060945c BindingDB Entry DOI: 10.7270/Q29K4C1S
Universitat de Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Bos taurus (bovine))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Universitat de Barcelona Curated by ChEMBL					Assay Description Inhibition of bovine erythrocyte AChE				J Med Chem 49: 6833-40 (2006) Article DOI: 10.1021/jm060945c BindingDB Entry DOI: 10.7270/Q29K4C1S
Universitat de Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
The Hong Kong University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of AChE in Sprague-Dawley rat cortices using acetylthiocholine iodide as substrate by Ellman's method				Bioorg Med Chem 21: 676-83 (2013) Article DOI: 10.1016/j.bmc.2012.11.044 BindingDB Entry DOI: 10.7270/Q20C4X3F
					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Inhibition of AChE (unknown origin)				Bioorg Med Chem Lett 23: 1544-7 (2013) Article DOI: 10.1016/j.bmcl.2012.11.083 BindingDB Entry DOI: 10.7270/Q2FB549P
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate measured after 20 mins by Ellman's method				J Med Chem 59: 8326-44 (2016) Article DOI: 10.1021/acs.jmedchem.6b00636 BindingDB Entry DOI: 10.7270/Q24T6MBB
					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Electrophorus electricus (Electric eel))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of electric eel AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's method				J Nat Prod 74: 997-1002 (2011) Article DOI: 10.1021/np100889v BindingDB Entry DOI: 10.7270/Q21V5FXX
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) (Rattus norvegicus (rat))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of rat serum BChE using butyrylthiocholine iodide as substrate after 20 mins by by Ellman's method				Bioorg Med Chem 26: 3117-3125 (2018) Article DOI: 10.1016/j.bmc.2018.04.037 BindingDB Entry DOI: 10.7270/Q28P631Z
					More data for this Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) (Rattus norvegicus (rat))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 20 mins by by Ellman's method				Bioorg Med Chem 26: 3117-3125 (2018) Article DOI: 10.1016/j.bmc.2018.04.037 BindingDB Entry DOI: 10.7270/Q28P631Z
					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Xinjiang Technical Institute of Physics and Chemistry Curated by ChEMBL					Assay Description Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured afte...				J Nat Prod 81: 2115-2119 (2018) Article DOI: 10.1021/acs.jnatprod.8b00461 BindingDB Entry DOI: 10.7270/Q25D8VGZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) (Rattus norvegicus (rat))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of AChE in rat cortex homogenate using acetylthiocholine iodide as substrate after 20 mins by Ellman's method				Eur J Med Chem 143: 33-47 (2018) Article DOI: 10.1016/j.ejmech.2017.08.025 BindingDB Entry DOI: 10.7270/Q2C53PC3
					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) (Rattus norvegicus (rat))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of BuChE in rat serum using butyrylthiocholine iodide as substrate after 20 mins by Ellman's method				Eur J Med Chem 143: 33-47 (2018) Article DOI: 10.1016/j.ejmech.2017.08.025 BindingDB Entry DOI: 10.7270/Q2C53PC3
					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate after 5 mins by spectrophotometric analysis				J Nat Prod 82: 792-797 (2019) Article DOI: 10.1021/acs.jnatprod.8b00705
Nanjing University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cholinesterases; ACHE & BCHE (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Charles University Curated by ChEMBL					Assay Description Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's method				J Nat Prod 82: 239-248 (2019) Article DOI: 10.1021/acs.jnatprod.8b00592
Charles University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Charles University Curated by ChEMBL					Assay Description Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's method				J Nat Prod 82: 239-248 (2019) Article DOI: 10.1021/acs.jnatprod.8b00592
Charles University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholinesterase (Electrophorus electricus (Electric eel))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	5.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hebei University Curated by ChEMBL					Assay Description Inhibition of Electric eel AChE using acetylcholine iodide as substrate by spectrophotometry based Ellman's method				Bioorg Med Chem Lett 30: (2020)
Hebei University Curated by ChEMBL					More data for this Ligand-Target Pair
Carboxylic ester hydrolase (Rattus norvegicus (rat))	BDBM50199522 ((+)-huperzine A \| (+-)-HA \| (-)-1-Amino-13-ethylid...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of BuChE in rat serum				Bioorg Med Chem 15: 1394-408 (2007) Article DOI: 10.1016/j.bmc.2006.11.009 BindingDB Entry DOI: 10.7270/Q27W6BTX
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair