BDBM50199683 3-(8-amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)phenol::CHEMBL245407

SMILES: Nc1nccn2c(nc(-c3cccc(O)c3)c12)C1CCC1

InChI Key: InChIKey=FYHLIVYLLJCASJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50199683   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50199683 (3-(8-amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)...) Show SMILES Nc1nccn2c(nc(-c3cccc(O)c3)c12)C1CCC1 Show InChI InChI=1S/C16H16N4O/c17-15-14-13(11-5-2-6-12(21)9-11)19-16(10-3-1-4-10)20(14)8-7-18-15/h2,5-10,21H,1,3-4H2,(H2,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	520	n/a	n/a	n/a	n/a	n/a	n/a
OSI Pharmaceuticals, Inc Curated by ChEMBL					Assay Description Inhibition of IGF-1R by ELISA				Bioorg Med Chem Lett 21: 2092-7 (2011) Article DOI: 10.1016/j.bmcl.2011.01.139 BindingDB Entry DOI: 10.7270/Q23N23QH
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50199683 (3-(8-amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)...) Show SMILES Nc1nccn2c(nc(-c3cccc(O)c3)c12)C1CCC1 Show InChI InChI=1S/C16H16N4O/c17-15-14-13(11-5-2-6-12(21)9-11)19-16(10-3-1-4-10)20(14)8-7-18-15/h2,5-10,21H,1,3-4H2,(H2,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	518	n/a	n/a	n/a	n/a	n/a	n/a
OSI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-IGF1R activity				Bioorg Med Chem Lett 17: 1091-7 (2007) Article DOI: 10.1016/j.bmcl.2006.11.016 BindingDB Entry DOI: 10.7270/Q2QZ29MB
					More data for this Ligand-Target Pair