BDBM50200526 CHEMBL1234118
SMILES: OC(=O)[C@@H]1CC(F)(F)CN1C[C@H]1CC[C@H]2CN[C@@H](C[C@H]2C1)C(O)=O
InChI Key: InChIKey=OXQXJYQSWZFDBB-WJTVCTBASA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human)) | BDBM50200526 (CHEMBL1234118) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Displacement of [3H]-kainate from human recombinant GluK2 receptor expressed in HEK293 cell membranes after 60 mins | Bioorg Med Chem Lett 26: 5568-5572 (2016) Article DOI: 10.1016/j.bmcl.2016.09.075 BindingDB Entry DOI: 10.7270/Q29S1T0N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate receptor ionotropic kainate (Homo sapiens (Human)) | BDBM50200526 (CHEMBL1234118) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University Curated by ChEMBL | Assay Description Displacement of [3H]kainate from human GluK1 expressed in HEK293 cell membranes after 60 mins by scintillation counting method | J Med Chem 60: 441-457 (2017) BindingDB Entry DOI: 10.7270/Q2G44SJJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutamate receptor ionotropic kainate (Homo sapiens (Human)) | BDBM50200526 (CHEMBL1234118) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University Curated by ChEMBL | Assay Description Inhibition of GluK3 (unknown origin) | J Med Chem 60: 441-457 (2017) BindingDB Entry DOI: 10.7270/Q2G44SJJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Grik5 (Homo sapiens (Human)) | BDBM50200526 (CHEMBL1234118) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College Curated by ChEMBL | Assay Description Displacement of [3H]-kainate from human recombinant GluK5 receptor expressed in HEK293 cell membranes after 60 mins | Bioorg Med Chem Lett 26: 5568-5572 (2016) Article DOI: 10.1016/j.bmcl.2016.09.075 BindingDB Entry DOI: 10.7270/Q29S1T0N | |||||||||||
More data for this Ligand-Target Pair |