BDBM50200634 (R)-4-(6-(2-(2-ethylpyrrolidin-1-yl)ethyl)naphthalen-2-yl)benzonitrile::CHEMBL246680

SMILES: CC[C@@H]1CCCN1CCc1ccc2cc(ccc2c1)-c1ccc(cc1)C#N

InChI Key: InChIKey=TUQVPFOSCLENLF-RUZDIDTESA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50200634   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50200634 ((R)-4-(6-(2-(2-ethylpyrrolidin-1-yl)ethyl)naphthal...) Show SMILES CC[C@@H]1CCCN1CCc1ccc2cc(ccc2c1)-c1ccc(cc1)C#N Show InChI InChI=1S/C25H26N2/c1-2-25-4-3-14-27(25)15-13-19-5-10-24-17-23(12-11-22(24)16-19)21-8-6-20(18-26)7-9-21/h5-12,16-17,25H,2-4,13-15H2,1H3/t25-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.61	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in C6 cells				Bioorg Med Chem Lett 17: 1443-6 (2007) Article DOI: 10.1016/j.bmcl.2006.11.073 BindingDB Entry DOI: 10.7270/Q2416WR3
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50200634 ((R)-4-(6-(2-(2-ethylpyrrolidin-1-yl)ethyl)naphthal...) Show SMILES CC[C@@H]1CCCN1CCc1ccc2cc(ccc2c1)-c1ccc(cc1)C#N Show InChI InChI=1S/C25H26N2/c1-2-25-4-3-14-27(25)15-13-19-5-10-24-17-23(12-11-22(24)16-19)21-8-6-20(18-26)7-9-21/h5-12,16-17,25H,2-4,13-15H2,1H3/t25-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	33.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in rat cortical membranes				Bioorg Med Chem Lett 17: 1443-6 (2007) Article DOI: 10.1016/j.bmcl.2006.11.073 BindingDB Entry DOI: 10.7270/Q2416WR3
					More data for this Ligand-Target Pair