BDBM50200640 (R)-4-(6-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)ethyl)naphthalen-2-yl)benzonitrile::CHEMBL392443

SMILES: OC[C@H]1CCCN1CCc1ccc2cc(ccc2c1)-c1ccc(cc1)C#N

InChI Key: InChIKey=CFEZMRAKKACDRJ-XMMPIXPASA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50200640   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50200640 ((R)-4-(6-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)ethy...) Show SMILES OC[C@H]1CCCN1CCc1ccc2cc(ccc2c1)-c1ccc(cc1)C#N Show InChI InChI=1S/C24H24N2O/c25-16-19-4-6-20(7-5-19)22-10-9-21-14-18(3-8-23(21)15-22)11-13-26-12-1-2-24(26)17-27/h3-10,14-15,24,27H,1-2,11-13,17H2/t24-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.89	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in C6 cells				Bioorg Med Chem Lett 17: 1443-6 (2007) Article DOI: 10.1016/j.bmcl.2006.11.073 BindingDB Entry DOI: 10.7270/Q2416WR3
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50200640 ((R)-4-(6-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)ethy...) Show SMILES OC[C@H]1CCCN1CCc1ccc2cc(ccc2c1)-c1ccc(cc1)C#N Show InChI InChI=1S/C24H24N2O/c25-16-19-4-6-20(7-5-19)22-10-9-21-14-18(3-8-23(21)15-22)11-13-26-12-1-2-24(26)17-27/h3-10,14-15,24,27H,1-2,11-13,17H2/t24-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	42.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in rat cortical membranes				Bioorg Med Chem Lett 17: 1443-6 (2007) Article DOI: 10.1016/j.bmcl.2006.11.073 BindingDB Entry DOI: 10.7270/Q2416WR3
					More data for this Ligand-Target Pair