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SMILES: O[C@@H]1CCN(CCc2ccc3cc(ccc3c2)-c2ccc(cc2)C#N)C1

InChI Key: InChIKey=YHMZHAITUOKJPI-HSZRJFAPSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50200648   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50200648
PNG
((R)-4-(6-(2-(3-hydroxypyrrolidin-1-yl)ethyl)naphth...)
Show SMILES O[C@@H]1CCN(CCc2ccc3cc(ccc3c2)-c2ccc(cc2)C#N)C1
Show InChI InChI=1S/C23H22N2O/c24-15-18-2-4-19(5-3-18)21-8-7-20-13-17(1-6-22(20)14-21)9-11-25-12-10-23(26)16-25/h1-8,13-14,23,26H,9-12,16H2/t23-/m1/s1
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KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.56n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in C6 cells


Bioorg Med Chem Lett 17: 1443-6 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.073
BindingDB Entry DOI: 10.7270/Q2416WR3
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50200648
PNG
((R)-4-(6-(2-(3-hydroxypyrrolidin-1-yl)ethyl)naphth...)
Show SMILES O[C@@H]1CCN(CCc2ccc3cc(ccc3c2)-c2ccc(cc2)C#N)C1
Show InChI InChI=1S/C23H22N2O/c24-15-18-2-4-19(5-3-18)21-8-7-20-13-17(1-6-22(20)14-21)9-11-25-12-10-23(26)16-25/h1-8,13-14,23,26H,9-12,16H2/t23-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
30.9n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in rat cortical membranes


Bioorg Med Chem Lett 17: 1443-6 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.073
BindingDB Entry DOI: 10.7270/Q2416WR3
More data for this
Ligand-Target Pair