BDBM50201030 CHEMBL3929689

SMILES: Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc(OCCOP(O)(O)=O)nc(c1)N1CCOCC1

InChI Key: InChIKey=GSZIABJCIKNHNN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50201030   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50201030 (CHEMBL3929689) Show SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc(OCCOP(O)(O)=O)nc(c1)N1CCOCC1 Show InChI InChI=1S/C25H26F3N4O7P/c1-16-2-3-19(30-24(33)17-4-5-29-21(12-17)25(26,27)28)15-20(16)18-13-22(32-6-8-37-9-7-32)31-23(14-18)38-10-11-39-40(34,35)36/h2-5,12-15H,6-11H2,1H3,(H,30,33)(H2,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Inhibition of 1 to 324 residues truncated c-Raf (unknown origin) expressed in baculovirus infected Sf9 insect cells using full length biotinylated ME...				ACS Med Chem Lett 7: 1022-1023 (2016) Article DOI: 10.1021/acsmedchemlett.6b00435 BindingDB Entry DOI: 10.7270/Q27S7QRX
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