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BDBM50201363 1-methyl-4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethoxy)phenyl)-1H-pyrazole-5-carboxamide::CHEMBL401040

SMILES: Cn1ncc(NCc2ccncc2)c1C(=O)Nc1ccc(OC(F)(F)F)cc1

InChI Key: InChIKey=MCIJHEGABQVOTC-UHFFFAOYSA-N

Data: 1 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50201363   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50201363
PNG
(1-methyl-4-(pyridin-4-ylmethylamino)-N-(4-(trifluo...)
Show SMILES Cn1ncc(NCc2ccncc2)c1C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C18H16F3N5O2/c1-26-16(15(11-24-26)23-10-12-6-8-22-9-7-12)17(27)25-13-2-4-14(5-3-13)28-18(19,20)21/h2-9,11,23H,10H2,1H3,(H,25,27)
PDB
MMDB

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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.170n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by [32P]ATP-competitive radioassay


Bioorg Med Chem Lett 17: 1369-75 (2007)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50201363
PNG
(1-methyl-4-(pyridin-4-ylmethylamino)-N-(4-(trifluo...)
Show SMILES Cn1ncc(NCc2ccncc2)c1C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C18H16F3N5O2/c1-26-16(15(11-24-26)23-10-12-6-8-22-9-7-12)17(27)25-13-2-4-14(5-3-13)28-18(19,20)21/h2-9,11,23H,10H2,1H3,(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 64n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cell-based assay


Bioorg Med Chem Lett 17: 1369-75 (2007)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50201363
PNG
(1-methyl-4-(pyridin-4-ylmethylamino)-N-(4-(trifluo...)
Show SMILES Cn1ncc(NCc2ccncc2)c1C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C18H16F3N5O2/c1-26-16(15(11-24-26)23-10-12-6-8-22-9-7-12)17(27)25-13-2-4-14(5-3-13)28-18(19,20)21/h2-9,11,23H,10H2,1H3,(H,25,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 730n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 by HTRF assay


Bioorg Med Chem Lett 17: 1369-75 (2007)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50201363
PNG
(1-methyl-4-(pyridin-4-ylmethylamino)-N-(4-(trifluo...)
Show SMILES Cn1ncc(NCc2ccncc2)c1C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C18H16F3N5O2/c1-26-16(15(11-24-26)23-10-12-6-8-22-9-7-12)17(27)25-13-2-4-14(5-3-13)28-18(19,20)21/h2-9,11,23H,10H2,1H3,(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.87E+3n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by HTRF assay


Bioorg Med Chem Lett 17: 1369-75 (2007)

More data for this
Ligand-Target Pair