null
SMILES: COC(=O)Nc1ccc(c(c1)[C@H]1CCCN1C(=O)[C@H](Nc1ccc2c(c[nH]c(=O)c2c1)C1CC1)c1ccc(OC)c(OC)c1)S(=O)(=O)C(C)C
InChI Key: InChIKey=CRBTZBQJUBHGJG-KAODMTDESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor VII/Tissue factor (Homo sapiens (Human)) | BDBM50201418 (CHEMBL3982319) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb R&D Curated by ChEMBL | Assay Description Inhibition of recombinant human factor-7a/TF using S2288 as substrate measured after 60 mins | ACS Med Chem Lett 7: 1077-1081 (2016) Article DOI: 10.1021/acsmedchemlett.6b00282 BindingDB Entry DOI: 10.7270/Q2GB2613 | |||||||||||
More data for this Ligand-Target Pair |