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BDBM50201949 2-biphenyl-4-yl-3-hydroxy-quinoline-4-carboxylic acid::CHEMBL219648

SMILES: OC(=O)c1c(O)c(nc2ccccc12)-c1ccc(cc1)-c1ccccc1

InChI Key: InChIKey=LXZMXHPFJHRHAD-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50201949   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydroorotate dehydrogenase


(Homo sapiens (Human))
BDBM50201949
PNG
(2-biphenyl-4-yl-3-hydroxy-quinoline-4-carboxylic a...)
Show SMILES OC(=O)c1c(O)c(nc2ccccc12)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H15NO3/c24-21-19(22(25)26)17-8-4-5-9-18(17)23-20(21)16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13,24H,(H,25,26)
PDB
MMDB

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Article
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n/an/a 10n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DHOD expressed in Escherichia coli


J Med Chem 50: 21-39 (2007)


Article DOI: 10.1021/jm0602256
BindingDB Entry DOI: 10.7270/Q2Z60PVV
More data for this
Ligand-Target Pair